Category: Healing

Terminal Cancer Patient Walks Out of Hospice after Treatment with Rick Simpson oil

Rick simpson oil

“After nine months of taking two different forms of cannabis oil, one, a cannabis capsule infused with organic coconut oil around 10:30am and high THC oil (Rick simpson oil) about an hour before bed, dad was given the life changing report, “No evidence of recurrent disease”.” [2]
– Corinne Malanca (Stan and Barb Rutner’s daughter)

Stan Found Cannabis after Chemo and Radiation Almost Killed Him

The trillion dollar burn, cut, poison, Cancer Industrial Complex boldly proclaims that chemotherapy and radiation routinely save lives – that their toxic interventions boost long-term survival rates and the biggest lie of all: chemo and radiation exclusively target cancerous cells and leave healthy cells alone.

All these statements by the cancer industry are patently false. Poison is poison; it kills indiscriminately. Chemo and radiation are poisons posing as medicine. In fact, mainstream cancer “treatment” is the leading cause of secondary cancers.

Dave Mihalovic a Naturopathic Doctor who specializes in vaccine research, cancer prevention and a holistic approach to cancer treatment stated:

“No chemotherapy drug has ever actually cured or resolved the underlying causes of cancer. Even what mainstream medicine considers “successful” chemotherapy treatments are only managing symptoms, usually at the cost of interfering with other precious physiological functions in patients that will cause side effects down the road.” [1]

Ironically, when chemo is killing cancer cells, it’s also stimulating healthy cells to produce a protein that supports tumor growth and makes the cells resistant to further cancer treatment.

Researchers Discover One of the Ways Chemo Enhances Cancer Growth

“The scientists found that healthy cells damaged by chemotherapy secreted more of a protein called WNT16B which boosts cancer cell survival.

“The increase in WNT16B was completely unexpected,” study co-author Peter Nelson of the Fred Hutchinson Cancer Research Center in Seattle told AFP.

The protein was taken up by tumor cells neighboring the damaged cells.
“WNT16B, when secreted, would interact with nearby tumor cells and cause them to grow, invade, and importantly, resist subsequent therapy,” said Nelson.

In cancer treatment, tumors often respond well initially, followed by rapid regrowth and then resistance to further chemotherapy.” [1]

 

The Stan Rutner Story

 

Stan and Barbara Rutner are a devoted, couple who have been together 59 years. They both have hard-won experience battling cancer. Roughly 25 years ago, Stan, a retired dentist with a lucrative mini-storage business was diagnosed with non-Hodgkin lymphoma, while Barb had successfully battled breast cancer twice. Stan remembers:”I just thought I had a cold, flu, type thing. That was it . . . I wasn’t thinking cancer at all.” [3]

After six months of aggressive, standard allopathic, treatment, Stan’s cancer was in remission – that was back in 1989. Meanwhile, Stan had moved on with his life; his bout with cancer faded into the deep dark recesses of his memory. Of course, Stan didn’t expect after all those years of remission he’d be fighting cancer again in 2011 but as mentioned above that’s not uncommon for those who undergo conventional cancer treatment. His initial symptom this time was a persistent cough, otherwise he seemed fine.

Somewhat concerned he made a doctor’s appointment. The initial diagnosis was early stage pneumonia. The doctor noted that there were some unusual looking spots on his lungs that needed follow-up, after the pneumonia had cleared. Numerous tests later and revealed the “spots” were cancerous nodes in the lungs. But there’s more. Stan’s final diagnosis: Stage 4 Lung Cancer with Metastasis to the Brain. Stan recalled how his doctor broke the news, ‘You’re in deep shit.’ Stan explained. “Yeah, he didn’t sugar coat it at all.” But it gets worse much worse. Down the road doctors discovered that the cancer had metastasized to his brain. [3]

Stan’s Health and Quality of life Rapidity Declined

This time, the chemotherapy and radiation, really took a heavy toll on Stan. Shortly after treatment began [march-April of 2012] Stan was plagued with debilitating fatigue, wasting away, weight loss and chronic nausea. Not a pretty picture especially for someone pushing 80.

Barb Rutner: “After that he was wiped out. He was very thin. So we finished radiation to his brain on June 25, and on July 13 he entered the hospital for the first time with radiation pneumonitis (inflammation of the lungs due to radiation therapy), so pneumonia. There were three hospital visits during that time, and on the third they kept him for a week and started him on oxygen 24/7. And then he went into palliative care.” [3]

Stan’s doctors gave him only weeks to live and ordered him to hospice, which he entered on August 12, 2011

The Rutners also used alternative treatments to ease Stan’s suffering and perhaps stall his “inevitable” death sentence. Stan tried Reiki energy treatments and acupuncture. He even attempted creative visualization but it wasn’t his thing and it didn’t really help him, although Barb had success with it when she was fighting breast cancer. Stan’s downward spiral continued unabated and time was running out. That’s when Corrine – Stan and Barb’s daughter and Corinne’s soon to be husband, John Malanca started researching Rick simpson oil as a possible treatment option for Stan.

Barb explains: “Corinne and John were becoming interested in Rick simpson oil but we were concerned that Stan was wasting away. He had lost so much weight and so we were anxious to get his appetite improved and help him with the nausea. So Corinne suggested Rick simpson oil. He started taking that in early November of 2011 and in the beginning, he took about a third of a dose in the morning, and it was about a week or two later that he was able to give up the extra oxygen that he had had 24/7.”[3]

Stan was ready to try Rick simpson oil – he realized better than anyone else that he had nothing to lose and maybe a lot to gain.
Stan stated: “No hesitation at all. Here I’m dying and getting nothing to change the course of things and so this thing has a pretty good track record in—what do you call it—in a non-medical world, so hey let’s try it. Got nothing to lose.” [3]

Stan’s Amazing Turnaround

Bingo! Within a couple of weeks of starting Rick simpson oil, Stan’s condition was improving in all ways. He started gaining weight, his sleep improved, he was regaining his strength. Eventually he ditched his walker, dumped his oxygen and started exercise classes. Barb described his progress as remarkable.

After several months of Cannabis Stan decided to get an MRI to check his progress

Barb: “On January 27, 2013 we received the results of Stan’s brain MRI in an email from his oncologist, stating simply: “IMPRESSION: No evidence of recurrent disease.” The lung cancer that had metastasized to his brain in the summer of 2011 (and nearly taken his life) was GONE! The doctor calls him a miracle man. We are deeply grateful to his “team” of doctors, friends and family, but we’ll always believe that Rick simpson oil turned the tide.” [3]

Barb and Stan Rutner at their Daughter’s
Wedding on September 21, 2013

“Dad never thought that he would make it to that day but low and behold, he continued on the Cannabis Oil and is STILL in remission!”- Corinne Malanca [2]

 

Cannabis Cures Cancer The Stan Rutner Story

Many Alternative Cancer Cures Exist and Have Been Suppressed – Kimberly Carter Gamble

Paul Fassa is a contributing staff writer for REALfarmacy.com. His pet peeves are the Medical Mafia’s control over health and the food industry and government regulatory agencies’ corruption. Paul’s valiant contributions to the health movement and global paradigm shift are world renowned. Visit his blog by following this link and follow him on Twitter here.

Sources:
[1] http://www.bibliotecapleyades.net/salud/salud_defeatcancer164.htm
[2] http://www.unitedpatientsgroup.com/blog/2014/03/20/dads-update-stan-rutner-a-cancer-survivor/
[3] http://ireadculture.com/article-2940-convinced-of-the-cure.html
http://cannajournal.com/2014/01/31/cannabis-cures-cancer-all-the-proof-you-need-3/
http://la.indymedia.org/news/2014/07/264847.php

If you like to obtain teh same oil as Rick simpson makes, write me an email.

Kanker is geen ziekte, maar… een vitamine B17-deficiëntie

We zijn voortdurend bang voor het woord kanker. We zijn omringd met mensen die er last van hebben, en het lijkt erop dat niemand deze dodelijke ziekte kan verslaan. Echter het is niet een echte ziekte. Kanker is een business, en wij betalen de prijs.
Miljoenen mensen lijden aan kanker, ongeacht hun leeftijd en geslacht. Echter, de meeste van hen zijn nog steeds niet bewust van het feit dat ze worden gemanipuleerd. Kanker is slechts een vitamine B17-deficiëntie (Amygdalin).
April 30, 2017

Er is een boek met de titel “World Without Cancer”, wat niet vertaald mocht worden in verschillende andere talen.

Echter, ons doel vandaag is om je ervan te overtuigen dat er geen kanker is, want het is slechts een vitamine B17-deficiëntie (Amygdalin). Daarom geen chirurgie, bestraling, chemotherapie en andere conventionele behandelingen.
In het verleden stierven zeelieden aan scheurbuik, en zo veel mogelijk mensen profiteerde daarvan, en later werd ontdekt dat het niet een echte ziekte was, maar slechts een tekort aan vitamine C.

Wij geloven dat dit hetzelfde is! De kanker-industrie is een enorme business, en miljarden euro’s worden jaarlijks verdiend. Het bloeide na de Tweede Wereldoorlog.
Echter, wanneer we rekening houden met het feit dat de genezing al lang geleden is gevonden, is de conclusie meer dan duidelijk: kanker vult de zakken van de kolonisatoren.
Toch kan kanker worden voorkomen door het volgen van deze eenvoudige tips:
Raak niet in paniek, maar onderzoek je conditie, en probeer uit te vinden wat voor type kanker je hebt.

Omdat kanker slechts een gebrek is aan vitamine B17 in het lichaam, zou je 15 tot 20 stukjes abrikoos steen / kern (fruit steen) per dag moeten eten om kanker te voorkomen.
Tarwe knoppen zijn een krachtige anti-kanker geneesmiddel, rijk aan vloeibare zuurstof en de meest krachtige anti-kanker verbinding-laetrile, een geëxtraheerde vorm van deze vitamine, word in de vrucht steen van appels gevonden.
Laetrile wordt geproduceerd in Mexico, en gesmokkeld naar de Verenigde Staten, omdat de geneesmiddel industrie bij wet verbiedt de productie van laetrile.

Dr. Harold W. Manner, de auteur van het boek “Death of Cancer”, beweert dat laetrile kanker behandelt in meer dan 90% van de gevallen.

Amygdalin (vitamine B17) is te vinden in:
De vrucht steen of graan (zaad) van fruit in de hoogste concentratie. Deze vruchten zijn: peren, appels, abrikozen, pruimen en perziken.
Zaden (granen): sesam en lijnzaad (zaad van linnen / vlaszaad).
Havermout , mortels van blok tarwe, gerst, bruine rijst, rogge, lijnzaad, gierst. Snijbonen, bonen, linzen spruit (linzen knop), granen, Lima (Lima bonen) en erwten.
Moerbei- zaden: Bittere amandelen (dat is de rijkste bron van vitamine B-17 van aard) en Indische amandel.
Moerbeien: bosbessen, zwarte moerbei, framboos en aardbei.
Zoete pompoen, biergist, en ruwe rijst (padie).
Dit zijn de rijkste bronnen van absorbeerbare B17:
Abrikozen (pitten / zaden)
bosbessen
vlierbessen
zaden van vruchten zoals kersen, appels, peren, perziken, pruimen
tuinbonen
amandelen
frambozen
Sorghum
Macadamia noten
aardbeien
bramen
tarwegras
Boekweit
limabonen
Gerst
cashewnoten
Taugé
Gierst

Bron: http://wtfbro.nl/een-geheim-is-blootgelegd-kanker-is-geen-ziekte-maar/

Italian Doctor: Cancer Is a Fungus That Can Be Treated With Sodium Bicarbonate

According to Italian doctor Tulio Simonchini, cancer is nothing but a fungus which can be eliminated with Sodium Bicarbonate (baking soda). Dr. Simonchini used this method to cure thousands of patients suffering from different types of cancer, and claims that it is 100% effective.

Sodium BicarbonateThe therapy isn’t harmful at all and let’s face it – you’ve got nothing to lose. The painful reality of more and more cancer cases is somehow connected to the failures of oncology. “We have to prove that modern oncology is unable to answer all the questions cancer patients have. It’s our moral and ethical commitment to find the real cure for the hardest and deadliest diseases of our time,” says Dr. Simonchini.

Cancer is a fungus!

“About a century ago, there was a great theory that cancer is caused by malfunctioning genes, which means that the disease is intracellular. However, in my opinion, cancer is a fungal infection and a special cellular phenomenon,” says Dr. Simonchini, who has sent shockwaves around the medical community with his claim.

CandidaIn the plant world, carcinoma is caused by fungal infections, and the same happens in humans. Fungi always carry a tumor with them – this has been proven in both in vivo and in vitro studies. However, scientists believe that they develop after the disease appeared. Dr. Simonchini believes that they were already there before – fungi create cancer, weaken our immune system and then attack the whole body.

Every type of cancer is caused by the Candida fungus, which has been confirmed by several studies, and its histological structure is a result of the defensive measures against the invasion. Over time, our tissues are weakened and tired, and they start producing unidentified cells.According to Dr. Simonchini, cancer is an “ulcer” where deformed cells accumulate and form colonies.

Baking soda

The usual antifungal drugs are ineffective against cancer as they only attack the surface of the cells. The main infection is more powerful than a single bacterium, which is why fungal infections last for so long.

“I have identified the things that can attack these colonies of fungi – for cancer, it’s Sodium Bicarbonatebaking soda, and a iodine tincture is the best substance for skin cancer,” claims Dr. Simonchini.

Many studies have confirmed baking soda’s intracellular action against cancer.

The treatment

“I have used the treatment on my patients for more than 20 years. Many of these patients have completely recovered from the disease. Even when doctors gave them no chances. The best way to eliminate a tumor is for it to come in contact with Sodium Bicarbonate, baking soda. Sodium Bicarbonate can be applied as an enema for digestive cancers, intravenous injection for brain and lung tumors and inhalation for tumors in the upper respiratory system. Breast, lymph system and subcutaneous tumors can be treated with a local perfusion. Internal organ tumors should be treated with baking soda by applying it directly into the arteries. It’s also important to treat every type of cancer with the proper dose,” Dr. Simonchini explains, and continues:

“For phleboclisis, you’ll need about 500 cm. of 5% or 8.4% solution; in some cases, the mixture only needs to be salty enough. During every treatment, it’s important to know that tumor colonies come back between the 3 and 4 day, and suffer a collapse between the 4 and 5 day, so a minimum of 6 days of treatment is required. The treatment should be repeated for 4 cycles, and has no other side-effects other than thirst and weakness.”

“For skin cancer, you should rub a 0.7% iodine tincture on the affected areas 20-30 times a day. Afterwards, the tumor will not return,” Dr. Simonchini says.

Here are the main symptoms of Candida infection: Chronic fatigue; Obsessive-compulsive disorder; Anxiety and irritability; Brain fog and nausea; Chronic skin disorders; Chronic digestive disorders; Mood changes; Starch and sugar cravings.

If you have notice at least 2 of these symptoms, you may have an advanced stage of candida infections which may result in cancer, so they should never be ignored.

Treatment and prevention of candida infections

The fungal development must be kept in check. Left untreated, candida can lead to candidiasis which can cause symptoms that mimic other diseases and result in perforation in the intestines and leaky gut syndrome. This will allow protein to attack your blood cells. In order to prevent further problems, we first need to eliminate the foods that feed candida – sugar and starch. This means no bread, candy, fresh fruit, pasta and rice for a while. Focus on eating raw fruit and steamed vegetables, and some people have had great results with grapefruit seeds. Dr. Simonchini recommends using aluminum-free baking soda for the treatment of cancer. It can be found in almost all health stores and pharmacies.

How the therapy works

Sodium Bicarbonate,Baking soda, significantly increases the alkalinity of your blood which destroys the fungi. Due to this, baking soda quickly disintegrates the tumor, leaving it without defense.

For stomach, colon, rectal and oral cancer, you need to take 1 teaspoon of Sodium Bicarbonate, baking soda, in a glass of water every morning and evening for a month. In most cases, this is enough time to eliminate the tumor. The therapy should last 3-4 weeks and not a day more. Dr. Simonchini’s therapy also usually requires intravenous injections as well. For best results, you’ll need 500 ml. of 5% baking soda solution applied in the vein directly every day. Do this for 24 days, then go for a scan. Vaginal fungal infections have become pretty common nowadays and according to Dr. Simonchini, they are the main culprit for cervical cancer and vaginal tumors. In order to treat these problems, you need to wash your vagina with a mixture made of 2 l. of filtered water and 2 tablespoons of baking soda. This will defeat the fungi that are causing the problem and prevent them from coming back in the future.

 

Source: An Italian Doctor Shocked the World: Cancer Is a Fungus That Can Be Treated With Baking Soda!(Video) – Collective Healthy

You’ll Freeze Lemons For The Rest Of Your Life!

So why should we freeze lemons?

hanging lemon“A new study has shown for the first time how limonoids, natural compounds present in lemons and other citrus fruit, impede both ER+ and ER- breast cancer cell growth. This sheds new light on the importance of citrus fruit for breast cancer prevention and supports past studies which showed fruit consumption may lower breast cancer risk.(1)”

All kinds of people are saying that the entire lemon should be used with nothing wasted. Not only for the obvious health benefits but also for the amazing taste! How? Simple, take an ORGANIC lemon, wash it and then put it in the freezer. Once it is frozen you get whatever is necessary to grate or shred the whole lemon without even peeling it first. Then sprinkle it on your salad, ice cream, soup, cereals, noodles, spaghetti sauce, or whatever. No holds barred. What you will experience is that whatever you sprinkle it on will take on a taste you may never have experienced before.

Why would I do this? Because the lemon peel contains 5 to 10 times more vitamins than the lemon juice itself and the peel is the part that is usually wasted. Not only that, but the peel helps to get rid of toxins in the body. But wait, there’s more. Lemon is effective in killing cancer cells because it is allegedly 10,000 stronger than chemotherapy. This has not been revealed because there are people out there that want to make a synthetic, toxic version that will bring them huge profits. Shades of Monsanto. The good news is that the taste of lemon is pleasant and does not deliver the horrific effects of chemotherapy. What’s bizarre is that people are closely guarding this fact so as to not jeopardize the income to those that profit from other’s illnesses. Another interesting aspect of the lemon is that it has a remarkable effect on cysts and tumors.

Always Freeze Your Lemons

Some say the lemon is a proven remedy against all types of cancer. It doesn’t end there. It has an anti-microbial effect against bacterial infections and fungi; it is effective against internal parasites and worms; it regulates blood pressure, which is too high; it acts as an anti-depressant; it combats stress and nervous disorders. The source of this information, although not specifically named, is one of the largest drug manufacturers in the world. They further say that after more than 20 laboratory tests since 1970, the extracts revealed that it destroys the malignant cells in 12 cancers, including colon, breast, prostate, lung and pancreas and that the compounds of the lemon tree were 10,000 times more effective than the product Adriamycin, which is a drug normally used chemotherapeutically in the world to slow the growth of cancer cells.

Even more, this type of therapy with lemon extract only destroys malignant cancer cells and does not affect healthy cells. The process is simple: buy an ORGANIC lemon, wash it, freeze it, grate it, and put it on everything you eat. It’s not rocket science. Nature has put stuff on the planet to keep the body healthy. The corporations hide this information and create synthetics to treat disease.

The synthetic chemical creates other symptoms from its ingestion requiring another drug to combat these symptoms. And so the cycle continues, which equates to enormous profits coming from an overt intention to keep a body ill and suppressing natural healing foods, minerals and modalities, all withheld by the mainstream media to not jeopardize their advertising dollar income, and payoffs to the politicians to not pass laws that will greatly benefit the people. If we do not take responsibility for ourselves and go against the mainstream grain, we will inevitably remain a “trick” our whole life.

Aloha!…

 

P.S. There are doctors who published studies and experiments in the 1940’s using liquid Vitamin C for the treatment of Cancer, and found that 40-60,000 units of liquid Vitamin C administered intraveinously not only cured the big “C”, but also left behind none of the side effects that chemotherapy does. The “frozen lemon” idea works on this same principal. You’re not likely to find too many Oncologists who are practicing the Vitamin C therapy due to two things: 1- the lack of knowledge of the natural world and how it pertains to our health, and, 2- there’s not a lot of income in the use of Lemons or Vitamin C in the treatment of Cancer. Look up Linus Pauling or Gerson Therapy (Dr. Max Gerson and the Gerson Institute, San Diego, CA. His daughter Charlotte has carried on her father’s legacy), and I’m sure you will eventually find what you are looking for. They did a lot of research with vitamin C during their lives.

 

credits: Real Farmacy, Natural News, Healthy Holistic Living

700 Medicinal uses of Cannabis sorted by dis-ease

Medicinal uses of Cannabis. A collection of clinical studies, papers and reference providing the ultimate resource for medical disorders helped by medical marijuana.

Source: Weedbay

medicinal uses of Cannabis

ADD/ ADHD

Marijuana and ADD Therapeutic uses of Medical Marijuana in the treatment of ADD
http://www.onlinepot.org/medical/add&mmj.htm

Cannabis as a medical treatment for attention deficit disorder –
http://www.chanvre-info.ch/info/en/…-treatment.html

Cannabinoids effective in animal model of hyperactivity disorder
http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=162#4

Cannabis ’Scrips to Calm Kids?
http://www.foxnews.com/story/0,2933,117541,00.html

Addiction risk- Physical

Women’s Guide to the UofC
http://wguide.uchicago.edu/9substance.html

Cannabis Basics
http://www.erowid.org/plants/cannabis/cannabis_basics.shtml

10 Things Every Parent, Teenager & Teacher Should Know About Marijuana (4th Q)
http://www.erowid.org/plants/cannabis/cannabis_flyer1.shtml

Marijuana Myths, Claim No. 9
http://www.erowid.org/plants/cannabis/cannabis_myth9.shtml

AIDS – see HIV

Alcoholism

Role of cannabinoid receptors in alcohol abuse
http://www.medicalnewstoday.com/articles/30338.php

Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity
http://jpet.aspetjournals.org/content/314/2/780.abstract?maxtoshow=&HITS=&hits=&RESULTFORMAT=&fulltext=cannabidiol%252Bantioxidants%252Bdiuretics%252Bneurotoxicity&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

Cannabis substitution
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=86

Cannabis as a Substitute for Alcohol
http://ccrmg.org/journal/03sum/substitutealcohol.html

ALS

Cannabinol delays symptom onset
http://www.ncbi.nlm.nih.gov/sites/e…t_uids=16183560

Marijuana in the management of amyotrophic lateral sclerosis
http://www.medscape.com/medline/abstract/11467101

Cannabis use in patients with amyotrophic lateral sclerosis.
http://www.medscape.com/medline/abstract/15055508

Cannabis Relieves Lou Gehrigs Symptoms
http://www.rense.com/general51/lou.htm

Cannabis’ Potential Exciting Researchers in Treatment of ALS, Parkinson’s Disease
http://66.218.69.11/search/cache?ei…&icp=1&.intl=us

Alzheimers

MARIJUANA SLOWS ALZHEIMER’S DECLINE
http://www.mapinc.org/drugnews/v05/n307/a10.html

Marijuana may block Alzheimer’s
http://news.bbc.co.uk/2/hi/health/4286435.stm

Prevention of Alzheimer’s Disease Pathology by Cannabinoids
http://www.jneurosci.org/cgi/content/abstract/25/8/1904

Marijuana’s Active Ingredient Shown to Inhibit Primary Marker of Alzheimer’s Disease
http://www.pacifier.com/~alive/articles/ca060809.htm

Dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=61

Dronabinol in the treatment of refractory agitation in Alzheimer’s disease
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=92

Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer’s disease.
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=59

Cannabinoids reduce the progression of Alzheimer’s disease in animals
http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=187#1

Molecular Link between the Active Component of Marijuana and Alzheimer’s Disease Pathology
http://www.unboundmedicine.com/medl…sease_Pathology

THC inhibits primary marker of Alzheimer’s disease
http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=225#3

Amotivational Syndrome

Amotivational Syndrome
http://leda.lycaeum.org/?ID=12454

Marijuana Myths, Claim No. 11
http://www.erowid.org/plants/cannab…is_myth11.shtml

Debunking ’Amotivational Syndrome’
http://www.mapinc.org/drugnews/v06/n400/a06.html

Amotivational Syndrome
http://www.bookrags.com/Amotivational_syndrome

Debunking the Amotivational Syndrome
http://www.drugscience.org/Petition/C3F.html

Cannabis Use Not Linked To So-Called “Amotivational Syndrome”
http://www.norml.org/index.cfm?Grou…tm_format=print

Anecdotal Evidence/First person stories
Shared Comments and Observations
http://www.rxmarihuana.com/comments…bservations.htm

Cannabis Sativa (Marijuana) for Fibromyalgia
http://www.fibromyalgia-reviews.com/Drg_Marijuana.cfm

ANECDOTAL ARTICLES
http://cannabislink.ca/medical/#medanecdotal

Testimonials
http://www.benefitsofmarijuana.com/testimonials.html

Excerpts of testimonials.
http://www.ganjaland.com/freemedicalseeds.htm

Appetite Stimulant

Dronabinol an effective appetite stimulant?
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=188

THC improves appetite and reverses weight loss in AIDS patients
http://www.cannabis-med.org/studies…ow.php?s_id=189

Efficacy of dronabinol alone and in combination
http://www.cannabis-med.org/studies…ow.php?s_id=191

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.
http://www.cannabis-med.org/studies…ow.php?s_id=190

The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies…ow.php?s_id=177

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases
http://www.cannabis-med.org/studies…ow.php?s_id=180

Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer’s disease
http://www.cannabis-med.org/studies…how.php?s_id=61

The perceived effects of smoked cannabis on patients with multiple sclerosis.
http://www.cannabis-med.org/studies…how.php?s_id=13

Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer’s disease
http://www.cannabis-med.org/studies…how.php?s_id=59

Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.
http://www.cannabis-med.org/studies…how.php?s_id=21

Delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia
http://www.cannabis-med.org/studies…how.php?s_id=52

Effect of dronabinol on nutritional status in HIV infection.
http://www.cannabis-med.org/studies…ow.php?s_id=150

Dronabinol stimulates appetite and causes weight gain in HIV patients.
http://www.cannabis-med.org/studies…how.php?s_id=20

Dronabinol effects on weight in patients with HIV infection.
http://www.cannabis-med.org/studies…how.php?s_id=45

Recent clinical experience with dronabinol.
http://www.cannabis-med.org/studies…how.php?s_id=90

Dronabinol enhancement of appetite in cancer patients.
http://www.cannabis-med.org/studies…ow.php?s_id=149

Effects of smoked marijuana on food intake and body weight
http://www.cannabis-med.org/studies…ow.php?s_id=117

Behavioral analysis of marijuana effects on food intake in humans.
http://www.cannabis-med.org/studies…ow.php?s_id=118

Cancer-related anorexia-cachexia syndrome
http://www.unboundmedicine.com/medl…xia_Study_Group

THC effective in appetite and weight loss in severe lung disease (COPD)
http://www.cannabis-med.org/english…el.php?id=191#2

Machinery Of The ’Marijuana Munchies’
http://www.sciencedaily.com/release…51226102503.htm

Arthritis

Cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
http://www.pnas.org/cgi/content/full/97/17/9561

The Cannabinergic System as a Target for Anti-inflammatory Therapies
http://www.ingentaconnect.com/conte…000013/art00008

Sativex in the treatment of pain caused by rheumatoid arthritis
http://rheumatology.oxfordjournals….bstract/45/1/50

Suppression of fibroblast metalloproteinases by ajulemic acid,
http://ccicnewsletter.com/index.php…06_Rheumatology

The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat
http://www.unboundmedicine.com/medl…binoid_receptor

Synergy between Delta(9)-tetrahydrocannabinol and morphine in the arthritic rat
http://www.unboundmedicine.com/medl…e_arthritic_rat

Cannabis based medicine eases pain and suppresses disease
http://www.medicalnewstoday.com/articles/33376.php

Pot-Based Drug Promising for Arthritis
http://www.webmd.com/rheumatoid-art…g-for-arthritis

Asthma

The Cannabinergic System as a Target for Anti-inflammatory Therapies
http://www.ingentaconnect.com/conte…000013/art00008

Acute and subacute bronchial effects of oral cannabinoids.
http://www.cannabis-med.org/studies…how.php?s_id=44

Comparison of bronchial effects of nabilone and terbutaline
http://www.cannabis-med.org/studies…how.php?s_id=43

Bronchial effects of aerosolized delta 9-tetrahydrocannabinol
http://www.cannabis-med.org/studies…ow.php?s_id=109

Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol
http://www.cannabis-med.org/studies…how.php?s_id=60

Effects of smoked marijuana in experimentally induced asthma.
http://www.cannabis-med.org/studies…how.php?s_id=57

Marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance
http://www.cannabis-med.org/studies…how.php?s_id=67

New Synthetic Delta-9-THC Inhaler Offers Safe, Rapid Delivery
http://www.medicalnewstoday.com/articles/22937.php

Smoked marijuana and oral delta-9-THC on specific airway conductance in asthmatic subjects
http://www.ukcia.org/research/Smoke…InAsthmatic.php

Atherosclerosis

Marijuana Chemical Fights Hardened Arteries
http://www.webmd.com/heart-disease/…rdened-arteries

Does Cannabis Hold the Key to Treating Cardiometabolic Disease
http://www.medscape.com/viewarticle/525040_print

Cannabis may keep arteries clear
http://www.gnn.tv/headlines/2634/Ca…_arteries_clear

The Cannabinergic System as a Target for Anti-inflammatory Therapies
http://www.ingentaconnect.com/conte…000013/art00008

Cannabis compound tackles blood vessel disease
http://www.medicalnewstoday.com/articles/22658.php

Medical marijuana: study shows that THC slows atherosclerosis
http://thenexthurrah.typepad.com/th…al_marijua.html

Cardiovascular Effects of Cannabis
http://www.idmu.co.uk/canncardio.htm

Atrophie Blanche

Atrophie Blanche Treated With Cannabis and/or THC
http://ccrmg.org/journal/04spr/clinical.html#thm

Autism

Autism and Medical Marijuana

THE SAM PROJECT: James D.
http://www.letfreedomgrow.com/articles/james_d.htm

Medical marijuana: a valuable treatment for autism?
http://www.autismwebsite.com/ari/ne…r/marijuana.htm

Cancer – breast

Anandamide inhibits human breast cancer cell proliferation
http://www.pnas.org/cgi/content/abstract/95/14/8375

Inhibition of Human Breast and Prostate Cancer Cell Proliferation1
http://endo.endojournals.org/cgi/co…tract/141/1/118

Antitumor Activity of Plant Cannabinoids
http://jpet.aspetjournals.org/cgi/c…ract/318/3/1375

9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer
http://cancerres.aacrjournals.org/c…ract/66/13/6615

Cannabidiol inhibits tumour growth in leukaemia and breast cancer
http://www.cannabis-med.org/english…el.php?id=220#2

THC and prochlorperazine effective in reducing vomiting in women following breast surgery
http://www.cannabis-med.org/english…el.php?id=219#1

Cancer- colorectal

Anandamide, induces cell death in colorectal carcinoma cells
http://gut.bmj.com/cgi/content/abstract/54/12/1741

Cannabinoids and cancer: potential for colorectal cancer therapy.
http://www.medscape.com/medline/abstract/16042581

Cancer- glioma/ brain

Anti-tumor effects of cannabidiol
http://www.hempworld.com/HempPharm/…milanstudy.html

Pot’s cancer healing properties
http://www.november.org/stayinfo/br…ncerKiller.html

Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
http://cancerres.aacrjournals.org/c…hort/64/16/5617

Inhibition of Glioma Growth in Vivo
http://cancerres.aacrjournals.org/c…/61/15/5784.pdf

Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.
http://www.cannabis-med.org/studies…ow.php?s_id=193

Cannabidiol triggers caspase activation and oxidative stress in human glioma cells.
http://www.ihop-net.org/UniPub/iHOP…l?pmid=16909207

Cannabinoid receptors in human astroglial tumors
http://www.brainlife.org/abstracts/…t_j20060800.pdf

Cannabis extract makes brain tumors shrink, halts growth of blood vessels
http://www.medicalnewstoday.com/articles/12088.php

THC tested against brain tumour in pilot clinical study
http://www.cannabis-med.org/english…el.php?id=222#1

Cancer- leukemia

Cannabis-induced cytotoxicity in leukemic cell lines
http://bloodjournal.hematologylibra…ract/105/3/1214

Cannabidiol-Induced Apoptosis in Human Leukemia Cells
http://molpharm.aspetjournals.org/c…stract/70/3/897

Marijuana’s Active Ingredient Kills Leukemia Cells
http://www.treatingyourself.com/vbu…read.php?t=7107

Targeting CB2 cannabinoid receptors to treat malignant lymphoblastic disease
http://bloodjournal.hematologylibra…t/100/2/627.pdf

Cannabinoids induce incomplete maturation of cultured human leukemia cells
http://www.osti.gov/energycitations…osti_id=5164483

Delta9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells
http://mcr.aacrjournals.org/cgi/con…bstract/4/8/549

Cannabidiol inhibits tumour growth in leukaemia and breast cancer
http://www.cannabis-med.org/english…el.php?id=220#2

Cancer- lung

Antineoplastic activity of cannabinoids
http://www.ukcia.org/research/Antin…ds/default.html

Delta(9)-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration
http://www.unboundmedicine.com/medl…astasis_in_vivo

Smoking Cannabis Does Not Cause Cancer Of Lung or Upper Airways
http://ccrmg.org/journal/05aut/nocancer.html

No association between lung cancer and cannabis smoking in large study
http://www.cannabis-med.org/english…el.php?id=219#2

Marijuana Smoking Found Non-Carcinogenic
http://www.medpagetoday.com/Hematol…gCancer/tb/3393

CLAIM #4: MARIJUANA CAUSES LUNG DISEASE
http://www.erowid.org/plants/cannab…bis_myth4.shtml

Cancer- melanoma

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.
http://www.cannabis-med.org/studies…ow.php?s_id=180

Intractable nausea and vomiting due to gastrointestinal mucosal metastases
http://www.cannabis-med.org/studies…how.php?s_id=35

Cancer – oral

Smoking of cannabis does not increase risk for oral cancer
http://www.cannabis-med.org/english…el.php?id=175#1

Marijuana use and Risk of Oral Squamous Cell Carcinoma
http://66.218.69.11/search/cache?ei…&icp=1&.intl=us

Cancer-pancreatic

Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells
http://cancerres.aacrjournals.org/c…ract/66/13/6748

Cancer – prostate

Inhibition of Human Breast and Prostate Cancer Cell Proliferation
http://endo.endojournals.org/cgi/co…tract/141/1/118

Cannabinoid Receptor as a Novel Target for the Treatment of Prostate Cancer
http://cancerres.aacrjournals.org/c…t/65/5/1635.pdf

Cancer – Risk Cannabis vs Tobacco

Cannabis Smoke and Cancer: Assessing the Risk
http://www.norml.org/index.cfm?Group_ID=6891

Cannabis and tobacco smoke are not equally carcinogenic
http://www.pubmedcentral.nih.gov/ar…i?artid=1277837

Smoking Marijuana Does Not Cause Lung Cancer
http://www.mapinc.org/drugnews/v05/n1065/a03.html

Blunt Smokers Link Dependence Potential To Nicotine
http://www.medicalnewstoday.com/articles/52838.php

Premiere British Medical Journal Pronounces Marijuana Safer Than Alcohol, Tobacco
http://cannabislink.ca/medical/safer.html

Why Doesn’t Smoking Marijuana Cause Cancer?
http://www.healthcentral.com/drdean/408/14275.html

Marijuana Smoking Found Non-Carcinogenic
http://www.medpagetoday.com/Hematol…gCancer/tb/3393


Cancer – Skin

Inhibition of skin tumor growth
http://www.jci.org/cgi/content/full…y=MpUgjDbqHybAU

Cannabis Reduces Skin Cancer
http://www.onlinepot.org/medical/skincancerreport.htm

Cancer – Testicular

The antiemetic efficacy of nabilone
http://www.cannabis-med.org/studies…ow.php?s_id=127

Chemotherapy for Testicular Cancer
http://www.rxmarihuana.com/shared_c…icularchemo.htm

Cancer –various/ unnamed
Derivatives of cannabis for anti-cancer treatment
http://www.eurekalert.org/pub_relea…uo-do060605.php

Cancer Killer
http://www.november.org/stayinfo/br…ncerKiller.html

Anandamide Induces Apoptosis
http://www.jbc.org/cgi/content/abstract/275/41/31938

Nabilone improves pain and symptom management
http://www.cannabis-med.org/studies…ow.php?s_id=177

The effects of smoked cannabis in painful peripheral neuropathy
http://www.cannabis-med.org/studies…how.php?s_id=96

Delta-9-tetrahydrocannabinol for appetite stimulation
http://www.cannabis-med.org/studies…how.php?s_id=52

Dronabinol and prochlorperazine in combination
http://www.cannabis-med.org/studies…how.php?s_id=28

Dronabinol enhancement of appetite in cancer patients.
http://www.cannabis-med.org/studies…ow.php?s_id=149

Efficacy of tetrahydrocannabinol
http://www.cannabis-med.org/studies…how.php?s_id=31

Inhalation marijuana as an antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=155

Nabilone versus domperidone
http://www.cannabis-med.org/studies…ow.php?s_id=129

Inhalation marijuana as an antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=155

Nabilone vs. placebo in chemotherapy-induced nausea and vomiting
http://www.cannabis-med.org/studies…ow.php?s_id=156

The antiemetic activity of tetrahydrocanabinol versus metoclopramide
http://www.cannabis-med.org/studies…how.php?s_id=24

Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy
http://www.cannabis-med.org/studies…show.php?s_id=5

Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate
http://www.cannabis-med.org/studies…how.php?s_id=23

Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy
http://www.cannabis-med.org/studies…how.php?s_id=27

Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-THC
http://www.cannabis-med.org/studies…ow.php?s_id=107

Superiority of nabilone over prochlorperazine as an antiemetic
http://www.cannabis-med.org/studies…ow.php?s_id=126

Analgesic effect of delta-9-tetrahydrocannabinol.
http://www.cannabis-med.org/studies…how.php?s_id=16

The analgesic properties of delta-9-tetrahydrocannabinol and codeine.
http://www.cannabis-med.org/studies…how.php?s_id=17

Comparison of orally administered cannabis extract and delta-9-THC
http://www.unboundmedicine.com/medl…xia_Study_Group

Cannabis May Help Combat Cancer-causing Herpes Viruses
http://www.sciencedaily.com/release…40923092627.htm

Marijuana Smoking Found Non-Carcinogenic
http://www.medpagetoday.com/Hematol…gCancer/tb/3393

Cannabidiol

Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity
http://jpet.aspetjournals.org/cgi/c…ourcetype=HWCIT

Cannabinol delays symptom onset
http://www.ncbi.nlm.nih.gov/sites/e…t_uids=16183560

Cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
http://www.pnas.org/cgi/content/full/97/17/9561

Cannabidiol inhibits tumour growth in leukaemia and breast cancer
http://www.cannabis-med.org/english…el.php?id=220#2

Anti-tumor effects of cannabidiol
http://www.hempworld.com/HempPharm/…milanstudy.html

Cannabidiol triggers caspase activation and oxidative stress in human glioma cells.
http://www.ihop-net.org/UniPub/iHOP…l?pmid=16909207

Cannabidiol-Induced Apoptosis in Human Leukemia Cells
http://molpharm.aspetjournals.org/c…stract/70/3/897

Cannabidiol inhibits tumour growth in leukaemia and breast cancer
http://www.cannabis-med.org/english…el.php?id=220#2

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice
http://www.ingentaconnect.com/conte…sn7o5efqr.alice

Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol
http://ajp.amjpathol.org/cgi/content/full/168/1/235

Evaluation of cannabidiol in dystonic movement disorders
http://www.cannabis-med.org/studies…how.php?s_id=14

Cannabidiol in dystonic movement disorders.
http://www.cannabis-med.org/studies…ow.php?s_id=139

Beneficial and adverse effects of cannabidiol in a Parkinson patient
http://www.cannabis-med.org/studies…ow.php?s_id=142

Treatment of Meige’s syndrome with cannabidiol.
http://www.cannabis-med.org/studies…ow.php?s_id=114

CANNABIDIOL TO HEALTHY VOLUNTEERS AND EPILEPTIC PATIENTS
http://web.acsalaska.net/~warmgun/es201.html

Chronic administration of cannabidiol to healthy volunteers and epileptic patients.
http://www.cannabis-med.org/studies…how.php?s_id=42

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol
http://www.unboundmedicine.com/medl…f_peroxynitrite

EFFECTS OF CANNABIDIOL IN HUNTINGTON’S DISEASE
http://www.druglibrary.org/schaffer…al/hunting1.htm

The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol.
http://www.medscape.com/medline/abstract/16209908

Cannabidiol has a cerebroprotective action
http://www.unboundmedicine.com/medl…iting_mechanism

Cannabidiol as an antipsychotic
http://www.cannabis-med.org/studies…ow.php?s_id=171

Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.
http://www.medscape.com/medline/abs…844117?prt=true

Who’s Afraid of Cannabidiol?
http://www.counterpunch.org/gardner07142007.html

Chemical composition

Cannabis: A source of useful pharma compounds
http://www.medpot.net/forums/index.php?showtopic=18608

Pharmacokinetics and cannabinoid action using oral cannabis extract
http://www.pharma-lexicon.com/medic…hp?newsid=29638

Pharmacokinetics of cannabinoids
http://66.218.69.11/search/cache?ei…&icp=1&.intl=us

The chemistry and biological activity of cannabis
http://www.unodc.org/unodc/en/bulle….html?print=yes

Differential effects of medical marijuana based on strain and route of administration
http://www.medicalmarijuanaprocon.o…trainsstudy.pdf

What is THC?
http://www.medicalmarijuanaprocon.o…1.0373456855945

Cannabis / Marijuana ( ? 9 -Tetrahydrocannabinol, THC)
http://www.nhtsa.dot.gov/people/inj…gs/cannabis.htm

Chemotherapy

Efficacy of dronabinol alone and in combination
http://www.cannabis-med.org/studies…ow.php?s_id=191

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases
http://www.cannabis-med.org/studies…ow.php?s_id=180

Intractable nausea and vomiting
http://www.cannabis-med.org/studies…how.php?s_id=35

An efficient new cannabinoid antiemetic in pediatric oncology
http://www.cannabis-med.org/studies…show.php?s_id=7

Dronabinol and prochlorperazine in combination
http://www.cannabis-med.org/studies…how.php?s_id=28

Marijuana as antiemetic medicine
http://www.cannabis-med.org/studies…ow.php?s_id=134

Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy
http://www.cannabis-med.org/studies…how.php?s_id=31

Inhalation marijuana as an antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=155

Nabilone versus prochlorperazine
http://www.cannabis-med.org/studies…ow.php?s_id=120

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=123

Antiemetic efficacy of nabilone and alizapride
http://www.cannabis-med.org/studies…ow.php?s_id=127

Nabilone versus domperidone
http://www.cannabis-med.org/studies…ow.php?s_id=129

THC or Compazine for the cancer chemotherapy patient
http://www.cannabis-med.org/studies…how.php?s_id=34

Comparison of nabilone and prochlorperazine
http://www.cannabis-med.org/studies…ow.php?s_id=128

Nabilone vs. prochlorperazine for refractory emesis
http://www.cannabis-med.org/studies…ow.php?s_id=146

Nabilone vs. placebo
http://www.cannabis-med.org/studies…ow.php?s_id=156

Tetrahydroannabinol (THC) vs prochlorperazine as chemotherapy antiemetics.
http://www.cannabis-med.org/studies…how.php?s_id=30

Comparative trial of the antiemetic effects of THC and haloperidol
http://www.cannabis-med.org/studies…how.php?s_id=64

Comparison of delta-9-tetrahydrocannabinol and prochlorperazine
http://www.cannabis-med.org/studies…show.php?s_id=3

Delta 9-tetrahydrocannabinol in cancer chemotherapy.
http://www.cannabis-med.org/studies…how.php?s_id=88

Antiemetic effect of tetrahydrocannabinol
http://www.cannabis-med.org/studies…show.php?s_id=6

Tetrahydrocanabinol versus metoclopramide and thiethylperazine
http://www.cannabis-med.org/studies…how.php?s_id=24

Effects of nabilone and prochlorperazine on chemotherapy-induced emesis
http://www.cannabis-med.org/studies…ow.php?s_id=131

Delta-9-tetrahydrocannabinol as an antiemetic
http://www.cannabis-med.org/studies…show.php?s_id=5

Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate
http://www.cannabis-med.org/studies…how.php?s_id=23

THC as an antiemetic in patients treated with cancer chemotherapy
http://www.cannabis-med.org/studies…how.php?s_id=27

Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-THC
http://www.cannabis-med.org/studies…ow.php?s_id=107

Superiority of nabilone over prochlorperazine
http://www.cannabis-med.org/studies…ow.php?s_id=126

Antiemetic effect of delta-9-tetrahydrocannabinol
http://www.cannabis-med.org/studies…show.php?s_id=4


Children

Experiences with THC-treatment in children and adolescents
http://www.cannabis-med.org/studies…how.php?s_id=80

An efficient new cannabinoid antiemetic in pediatric oncology.
http://www.cannabis-med.org/studies…show.php?s_id=7

Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children
http://www.cannabis-med.org/studies…ow.php?s_id=120

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=123

Marijuana and ADD Therapeutic uses of Medical Marijuana in the treatment of ADD
http://www.onlinepot.org/medical/add&mmj.htm

Oily fish makes ’babies brainier’
http://news.bbc.co.uk/2/hi/health/4631006.stm

Cannabis is a First-Line Treatment for Childhood Mental Disorders
http://www.counterpunch.org/mikuriya07082006.html

Ganja use among Jamaican women.
http://www.rism.org/isg/dlp/ganja/a…anjaBabyes.html

Dreher’s Jamaican Pregnancy Study
http://www.november.org/stayinfo/br…reherStudy.html

Cannabis Relieves Morning Sickness
http://ccrmg.org/journal/06spr/dreher.html#morning

Moderate cannabis use not harmful to the brain of adolescents, M R I study finds
http://www.cannabis-med.org/english…el.php?id=218#3

No brain structural change associated with adolescent cannabis use
http://www.pubmedcentral.nih.gov/bo…l&artid=1524733

No ’Smoking’ Gun: Research Indicates Teen Marijuana Use Does Not Predict Drug, Alcohol Abuse
http://www.sciencedaily.com/release…61204123422.htm

Pot May Not Shrink Teens’ Brains After All
http://www.medpagetoday.com/Neurolo…urology/tb/3242

Chronic Cystitis

Cannabinoid rotation in a young woman with chronic cystitis
http://www.cannabis-med.org/studies…ow.php?s_id=115


CPOD

THC effective in appetite and weight loss in severe lung disease (COPD)
http://www.cannabis-med.org/english…el.php?id=191#2

Heavy Long-Term Marijuana Use Does Not Impair Lung Function
http://www.erowid.org/plants/cannab…is_media7.shtml

Diabetes

Cannabinoid Reduces Incidence Of Diabetes
http://www.norml.org/index.cfm?Group_ID=6909

Marijuana Compound May Help Stop Diabetic Retinopathy
http://www.sciencedaily.com/release…60227184647.htm

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice
http://www.ingentaconnect.com/conte…sn7o5efqr.alice

Anticoagulant Effects of a Cannabis Extract in an Obese Rat Model
http://www.level1diet.com/research/id/14687

Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol
http://ajp.amjpathol.org/cgi/content/full/168/1/235

The Cannabinergic System as a Target for Anti-inflammatory Therapies
http://www.ingentaconnect.com/conte…000013/art00008

Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes
http://www.unboundmedicine.com/medl…d_diabetic_rats

Cannabidiol reduces the development of diabetes in an animal study
http://www.cannabis-med.org/english…el.php?id=219#3

Depression

Cannabinoids promote hippocampus neurogenesis and produce anxiolytic- and antidepressant
http://www.jci.org/cgi/content/full/115/11/3104

Antidepressant-like activity by blockade of anandamide hydrolysis
http://www.pubmedcentral.nih.gov/ar…bmedid=16352709

Decreased depression in marijuana users.
http://www.medscape.com/medline/abstract/15964704

Antidepressant-like activity
http://www.pubmedcentral.nih.gov/ar…bmedid=16352709

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.
http://www.cannabis-med.org/studies…ow.php?s_id=190

Nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies…ow.php?s_id=177

The perceived effects of smoked cannabis on patients with multiple sclerosis.
http://www.cannabis-med.org/studies…how.php?s_id=13

Cannabis and Depression
http://www.pacifier.com/~alive/cmu/…nd_cannabis.htm

Association between cannabis use and depression may not be causal, study says
http://www.cannabis-med.org/english…el.php?id=177#4

Marijuana use and depression among adults: Testing for causal associations.
http://www.ncbi.nlm.nih.gov/sites/e…Pubmed_RVDocSum

Do patients use marijuana as an antidepressant?
http://www.ncbi.nlm.nih.gov/sites/e…Pubmed_RVDocSum

Dermatitis

Efficacy of dietary hempseed oil in patients with atopic dermatitis.
http://www.medscape.com/medline/abs…ryText=hempseed

Dronabinol

Dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia
http://www.cannabis-med.org/studies…how.php?s_id=61

Dronabinol in the treatment of refractory agitation in Alzheimer’s disease
http://www.cannabis-med.org/studies…how.php?s_id=92

Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer’s disease.
http://www.cannabis-med.org/studies…how.php?s_id=59

Dronabinol an effective appetite stimulant?
http://www.cannabis-med.org/studies…ow.php?s_id=188

Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer’s disease
http://www.cannabis-med.org/studies…how.php?s_id=61

Effect of dronabinol on nutritional status in HIV infection.
http://www.cannabis-med.org/studies…ow.php?s_id=150

Dronabinol stimulates appetite and causes weight gain in HIV patients.
http://www.cannabis-med.org/studies…how.php?s_id=20

Dronabinol effects on weight in patients with HIV infection.
http://www.cannabis-med.org/studies…how.php?s_id=45

Recent clinical experience with dronabinol.
http://www.cannabis-med.org/studies…how.php?s_id=90

Dronabinol enhancement of appetite in cancer patients.
http://www.cannabis-med.org/studies…ow.php?s_id=149

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.
http://www.cannabis-med.org/studies…ow.php?s_id=180

Dronabinol and prochlorperazine in combination
http://www.cannabis-med.org/studies…how.php?s_id=28

Dronabinol enhancement of appetite in cancer patients.
http://www.cannabis-med.org/studies…ow.php?s_id=149

Efficacy of dronabinol alone and in combination
http://www.cannabis-med.org/studies…ow.php?s_id=191

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.
http://www.cannabis-med.org/studies…ow.php?s_id=190

Dronabinol and retinal hemodynamics in humans.
http://www.cannabis-med.org/studies…ow.php?s_id=202

Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension
http://www.cannabis-med.org/studies…ow.php?s_id=181

Nausea relieved by tetrahydrocannabinol (dronabinol).
http://www.cannabis-med.org/studies…how.php?s_id=35

Dronabinol in patients with intractable pruritus secondary to cholestatic liver disease.
http://www.cannabis-med.org/studies…ow.php?s_id=116

Treatment of spasticity in spinal cord injury with dronabinol
http://www.cannabis-med.org/studies…ow.php?s_id=112

Cannabinoid Activator Mellows Out Colon
http://www.medpagetoday.com/MeetingCoverage/ACG/tb/4410

Drug testing

Hemp oil causes positive urine tests for THC
http://www.druglibrary.org/crl/drug…0JAnToxicol.pdf

Dystonia

Cannabis sativa and dystonia secondary to Wilson’s disease.
http://www.medscape.com/medline/abstract/15390041

Experiences with THC-treatment in children and adolescents
http://www.cannabis-med.org/studies…how.php?s_id=80

Evaluation of cannabidiol in dystonic movement disorders
http://www.cannabis-med.org/studies…how.php?s_id=14

Cannabidiol in dystonic movement disorders.
http://www.cannabis-med.org/studies…ow.php?s_id=139

Beneficial and adverse effects of cannabidiol in a Parkinson patient
http://www.cannabis-med.org/studies…ow.php?s_id=142

Treatment of Meige’s syndrome with cannabidiol.
http://www.cannabis-med.org/studies…ow.php?s_id=114

Endocannabinoid Deficiency

Clinical Endocannabinoid Deficiency
http://www.freedomtoexhale.com/clinical.pdf

The endocannabinoid system is dysregulated in multiple sclerosis
http://brain.oxfordjournals.org/cgi…stract/awm160v1

Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
http://brain.oxfordjournals.org/cgi…ull/126/10/2191

Epilepsy

Epilepsy patients are smoking pot
http://www.safeaccessnow.org/article.php?id=1638

CANNABIDIOL TO HEALTHY VOLUNTEERS AND EPILEPTIC PATIENTS
http://web.acsalaska.net/~warmgun/es201.html

Experiences with THC-treatment in children and adolescents
http://www.cannabis-med.org/studies…how.php?s_id=80

Chronic administration of cannabidiol to healthy volunteers and epileptic patients.
http://www.cannabis-med.org/studies…how.php?s_id=42

Anticonvulsant nature of marihuana smoking.
http://www.cannabis-med.org/studies…how.php?s_id=39

Cannabis may help epileptics
http://www.medicalnewstoday.com/articles/4423.php

Hypnotic and Antiepileptic Effects of Cannabidiol
http://www.thecompassionclub.org/me…rue&pageNumber=

Marijuana: an effective antiepileptic treatment in partial epilepsy?
http://www.cannabis-med.org/studies…ow.php?s_id=157

Familial Mediterranean Fever

Pain relief with oral cannabinoids in familial Mediterranean fever.
http://www.cannabis-med.org/studies…how.php?s_id=18

Fertility

Synthetic Cannabinoid May Aid Fertility In Smokers
http://www.medicalnewstoday.com/articles/58063.php

Fever

A Novel Role of Cannabinoids
http://ccicnewsletter.com/index.php…nfectious_Disea

A Cooling Effect From Cannabis?
http://ccrmg.org/journal/05aut/coolcannabis.html

Fibromyalgia

Delta-9-THC based monotherapy in fibromyalgia patients
http://www.medscape.com/medline/abstract/16834825

Clinical Endocannabinoid Deficiency
http://www.freedomtoexhale.com/clinical.pdf

Cannabis Sativa (Marijuana) for Fibromyalgia
http://www.fibromyalgia-reviews.com/Drg_Marijuana.cfm

THC Reduces Pain in Fibromyalgia Patients
http://www.illinoisnorml.org/content/view/63/35/

Gateway Theory

The Myth of Marijuana’s Gateway Effect
http://www.druglibrary.org/schaffer/library/mjgate.htm

Endogenous cannabinoids are not involved in cocaine reinforcement
http://www.sciencedirect.com/scienc…a4e861a90579fac

No ’Smoking’ Gun: Research Indicates Teen Marijuana Use Does Not Predict Drug, Alcohol Abuse
http://www.sciencedaily.com/release…61204123422.htm

CLAIM #13:MARIJUANA IS A “GATEWAY” TO THE USE OF OTHER DRUGS
http://www.erowid.org/plants/cannab…is_myth13.shtml

Glaucoma

Marijuana Smoking vs Cannabinoids for Glaucoma Therapy
http://archopht.ama-assn.org/cgi/co…act/116/11/1433

Dronabinol and retinal hemodynamics in humans.
http://www.cannabis-med.org/studies…ow.php?s_id=202

Effect of Sublingual Application of Cannabinoids on Intraocular Pressure
http://www.cannabis-med.org/studies…ow.php?s_id=201

Delta 9-tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications.
http://www.cannabis-med.org/studies…how.php?s_id=88

Effect of marihuana on intraocular and blood pressure in glaucoma.
http://www.cannabis-med.org/studies…how.php?s_id=87

Effect of delta-9-tetrahydrocannabinol on intraocular pressure in humans.
http://www.cannabis-med.org/studies…how.php?s_id=40

Marihuana smoking and intraocular pressure.
http://www.cannabis-med.org/studies…how.php?s_id=47

Neuroprotective and Intraocular Pressure-Lowering Effects of (-)Delta-Tetrahydrocannabinol
http://www.unboundmedicine.com/medl…del_of_Glaucoma

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol
http://www.unboundmedicine.com/medl…f_peroxynitrite

Effects of tetrahydrocannabinol on arterial and intraocular hypertension.
http://www.medscape.com/medline/abstract/468444

Gynocology and obstetrics

Cannabis Treatments in Obstetrics and Gynecology: A Historical Review
http://www.freedomtoexhale.com/russo-ob.pdf

Heart Disease/ Cardiovascular

Marijuana Chemical Fights Hardened Arteries
http://www.webmd.com/heart-disease/…rdened-arteries

The endogenous cardiac cannabinoid system: a new protective mechanism
http://www.cannabinoid.com/boards/thd3x10073.shtml

Cardiovascular pharmacology of cannabinoids.
http://www.biowizard.com/story.php?pmid=16596789

Delta-9-tetrahydrocannabinol protects cardiac cells from hypoxia
http://www.ingentaconnect.com/conte…020001/00002346

Does Cannabis Hold the Key to Treating Cardiometabolic Disease?
http://www.medscape.com/viewarticle/525040_print

Cannabinoid Offers Cardioprotection
http://www.norml.org/index.cfm?Grou…tm_format=print

Heavy Cannabis Use Not Independently Associated With Cardiovascular Risks
http://www.norml.org/index.cfm?Group_ID=6972

Marijuana use, diet, body mass index, and cardiovascular risk factors
http://www.medscape.com/medline/abstract/16893701

Cannabinoids and cardiovascular disease
http://www.unboundmedicine.com/medl…ical_treatments

Cannabinoids as therapeutic agents in cardiovascular disease
http://www.unboundmedicine.com/medl…s_and_illusions

The in vitro and in vivo cardiovascular effects of Delta9-tetrahydrocannabinol
http://www.unboundmedicine.com/medl…_oxide_synthase

Cannabinoids prevented the development of heart failure in animal study
http://www.cannabis-med.org/english…el.php?id=145#2

Cannabis use not associated with risk factors for diseases of heart and circulation
http://www.cannabis-med.org/english…el.php?id=225#2

THC protects heart cells in the case of lowered oxygen supply
http://www.cannabis-med.org/english…el.php?id=212#1

Medical marijuana: study shows that THC slows atherosclerosis
http://thenexthurrah.typepad.com/th…al_marijua.html

Cardiovascular Effects of Cannabis
http://www.idmu.co.uk/canncardio.htm

Changes in middle cerebral artery velocity after marijuana
http://www.ncbi.nlm.nih.gov/sites/e…0&dopt=Abstract[/]

Hepatitis

Moderate Cannabis Use Associated with Improved Treatment Response
http://www.hivandhepatitis.com/hep_…6/091506_a.html

Cannabis use improves retention and virological outcomes in patients treated for hepatitis C
http://www.natap.org/2006/HCV/091506_02.htm

Hepatitis C – The Silent Killer Can Medical Cannabis Help?
http://www.pacifier.com/~alive/cmu/hepatitis_c.htm

Herpes

Cannabis May Help Combat Cancer-causing Herpes Viruses
http://www.sciencedaily.com/release…40923092627.htm

THC inhibits lytic replication of gamma oncogenic herpes viruses in vitro
http://www.pubmedcentral.nih.gov/bo…ml&artid=521080

Suppressive effect of delta-9-tetrahydrocannabinol on herpes simplex virus infectivity in vitro
http://www.ebmonline.org/cgi/content/abstract/196/4/401

Inhibition of cell-associated herpes simplex virus
http://www.ebmonline.org/cgi/content/abstract/185/1/41

The Effect of Delta-9-Tetrahydrocannabinol on Herpes Simplex Virus Replication
http://vir.sgmjournals.org/cgi/cont…stract/49/2/427

Hiccups

Marijuana cures hiccups
http://www.yourhealthbase.com/database/a77k.htm

Marijuana For Intractable Hiccups
http://cannabislink.ca/medical/hiccups.html

HIV / AIDS

Marijuana Use Does Not Accelerate HIV Infection
http://paktribune.com/news/print.php?id=139255

THC improves appetite and reverses weight loss in AIDS patients
http://www.cannabis-med.org/studies…ow.php?s_id=189

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.
http://www.cannabis-med.org/studies…ow.php?s_id=190

Cannabis in painful HIV-associated sensory neuropathy
http://www.cannabis-med.org/studies…ow.php?s_id=199

Smoked cannabis therapy for HIV-related painful peripheral neuropathy
http://www.cannabis-med.org/studies…ow.php?s_id=172

Short-term effects of cannabinoids in patients with HIV-1 infection
http://www.cannabis-med.org/studies…how.php?s_id=62

Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.
http://www.cannabis-med.org/studies…how.php?s_id=21

Effect of dronabinol on nutritional status in HIV infection.
http://www.cannabis-med.org/studies…ow.php?s_id=150

Dronabinol stimulates appetite and causes weight gain in HIV patients.
http://www.cannabis-med.org/studies…how.php?s_id=20

Dronabinol effects on weight in patients with HIV infection.
http://www.cannabis-med.org/studies…how.php?s_id=45

Recent clinical experience with dronabinol.
http://www.cannabis-med.org/studies…how.php?s_id=90

Marijuana as therapy for people living with HIV/AIDS: Social and health aspects
http://www.unboundmedicine.com/medl…_health_aspects

Marijuana and AIDS: A Four-Year Study
http://ccrmg.org/journal/05spr/aids.html

Historical studies

The La Guardia Committee Report
http://www.druglibrary.org/schaffer…lag/lagmenu.htm

Physical, Mental, and Moral Effects of Marijuana: The Indian Hemp Drugs Commission Report
http://www.druglibrary.org/schaffer/Library/effects.htm

MARIAJUANA SMOKING IN PANAMA
http://www.druglibrary.org/schaffer…ama/panama1.htm

The British Pharmaceutical Codex – 1934
http://www.druglibrary.org/schaffer…ical/brit34.htm

ON THE PREPARATIONS OF THE INDIAN HEMP, OR GUNJAH
http://www.druglibrary.org/schaffer…1850/gunjah.htm

DISPENSATORY OF THE UNITED STATES OF AMERICA Fifth Edition (1843)
http://www.druglibrary.org/schaffer…ry/dispensa.htm

New Remedies:Pharmaceutically and Therapeutically Considered Fourth Edition (1843)
http://www.druglibrary.org/schaffer…ry/dunglisn.htm

On the Haschisch or Cannabis Indica
http://www.druglibrary.org/schaffer…ry/bellhash.htm

ON INDICATIONS OF THE HACHISH-VICE IN THE OLD TESTAMENT
http://www.druglibrary.org/schaffer…tory/hashot.htm

The Physiological Activity of Cannabis Sativa
http://www.druglibrary.org/schaffer…istory/japa.htm

CANNABIS, U.S.P. (American Cannabis):
http://www.druglibrary.org/schaffer…ry/vbchmed1.htm

Hormones

Effects of chronic marijuana use on testosterone, luteinizing hormone, follicle stimulating …
http://www.anesth.uiowa.edu/readabs…sp?PMID=1935564

Marijuana: interaction with the estrogen receptor
http://jpet.aspetjournals.org/cgi/c…tract/224/2/404

Huntington’s Disease

EFFECTS OF CANNABIDIOL IN HUNTINGTON’S DISEASE
http://www.druglibrary.org/schaffer…al/hunting1.htm

Nabilone Could Treat Chorea and Irritability in Huntington’s Disease
http://neuro.psychiatryonline.org/c…/18/4/553?rss=1

Hysterectomy

Effect of nabilone on nausea and vomiting after total abdominal hysterectomy
http://www.cannabis-med.org/studies…ow.php?s_id=137

Idiopathic Intracranial Hypertension

Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension
http://www.cannabis-med.org/studies…ow.php?s_id=181

IQ

Findings of a longitudinal study of effects on IQ
http://www.cmaj.ca/cgi/content/full/166/7/887

Heavy cannabis use without long-term effect on global intelligence
http://www.cannabis-med.org/english…el.php?id=115#2

Marijuana does not dent IQ permanently
http://www.newscientist.com/article…ermanently.html

Marinol/Synthetics/ cannabinoid mixtures

CANNABIS AND MARINOL IN THE TREATMENT OF MIGRAINE HEADACHE
http://www.druglibrary.org/schaffer/hemp/migrn2.htm

Marinol vs Natural Cannabis
http://www.norml.org/pdf_files/NORM…al_Cannabis.pdf

The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol.
http://www.medscape.com/medline/abstract/16209908

Unheated Cannabis sativa extracts and its major compound THC-acid
http://www.medscape.com/medline/abs…504929?prt=true

Side effects of pharmaceuticals not elicited by comparable herbal medicines.
http://www.medscape.com/medline/abstract/10394675

Sativex in the treatment of pain caused by rheumatoid arthritis
http://rheumatology.oxfordjournals….bstract/45/1/50

Is dronabinol an effective appetite stimulant?
http://www.cannabis-med.org/studies…ow.php?s_id=188

Sativex in patients suffering from multiple sclerosis associated detrusor overactivity
http://www.cannabis-med.org/studies…ow.php?s_id=168

Sativex® in patients with symptoms of spasticity due to multiple sclerosis
http://www.cannabis-med.org/studies…ow.php?s_id=169

Nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies…ow.php?s_id=177

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases
http://www.cannabis-med.org/studies…ow.php?s_id=180

Synthetic cannabinomimetic nabilone on patients with chronic pain
http://www.cannabis-med.org/studies…ow.php?s_id=197

Nabilone significantly reduces spasticity-related pain
http://www.cannabis-med.org/studies…ow.php?s_id=200

Sativex produced significant improvements in a subjective measure of spasticity
http://www.cannabis-med.org/studies…ow.php?s_id=170

Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain
http://www.cannabis-med.org/studies…how.php?s_id=85

Cannabinoid rotation in a young woman with chronic cystitis
http://www.cannabis-med.org/studies…ow.php?s_id=115

Dronabinol in patients with intractable pruritus
http://www.cannabis-med.org/studies…ow.php?s_id=116

Cannabinoids reduce levodopa-induced dyskinesia in Parkinson’s disease:
http://www.cannabis-med.org/studies…how.php?s_id=54

Nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson’s disease
http://www.cannabis-med.org/studies…ow.php?s_id=153

Nabilone in the treatment of multiple sclerosis.
http://www.cannabis-med.org/studies…how.php?s_id=11

Big Pharma’s Strange Holy Grail: Cannabis Without Euphoria?
http://www.counterpunch.org/gardner07082006.html

Sativex showed positive effects in 65 per cent of patients with chronic diseases
http://www.cannabis-med.org/english…el.php?id=230#4


Meige’s Syndrome

Treatment of Meige’s syndrome with cannabidiol.
http://www.cannabis-med.org/studies…ow.php?s_id=114

Migraine/ Headache

CANNABIS AND MARINOL IN THE TREATMENT OF MIGRAINE HEADACHE
http://www.druglibrary.org/schaffer/hemp/migrn2.htm

Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension
http://www.cannabis-med.org/studies…ow.php?s_id=181

Cannabis and Migraine
http://www.pacifier.com/~alive/cmu/…nd_migraine.htm

Clinical Endocannabinoid Deficiency
http://www.freedomtoexhale.com/clinical.pdf

Hemp for Headache
http://www.freedomtoexhale.com/hh.pdf

Chronic Migraine Headache
http://www.druglibrary.org/schaffer/hemp/migrn1.htm

Morning Sickness
Medical marijuana: a surprising solution to severe morning sickness http://www.findarticles.com/p/artic…124/ai_n6015580

Medicinal cannabis use among childbearing women
http://safeaccess.ca/research/cannabis_nausea2006.pdf

Mortality Rates

Marijuana use and mortality.
http://www.pubmedcentral.nih.gov/ar…i?artid=1380837

Marijuana Smoking Doesn’t Lead to Higher Death Rate
http://ccrmg.org/journal/03sum/kaiser.html

How deadly is marijuana?
http://www.medicalnewstoday.com/articles/4426.php

MS

Sativex in patients with symptoms of spasticity due to multiple sclerosis
http://informahealthcare.com/doi/abs/10.1517/14656566.7.5.607

Marijuana derivatives may provide MS treatment
http://www.healthypages.net/news.asp?newsid=5381

Marijuana Helps MS Patients Alleviate Pain, Spasms
http://www.mult-sclerosis.org/news/…smsAndPain.html

Cannabis-based medicine in central pain in multiple sclerosis
http://www.neurology.org/cgi/conten…t/65/6/812?etoc

Cannabis-based medicine in spasticity caused by multiple sclerosis
http://www.cannabis-med.org/studies…ow.php?s_id=192

Sativex in patients suffering from multiple sclerosis associated detrusor overactivity
http://www.cannabis-med.org/studies…ow.php?s_id=168

The effect of cannabis on urge incontinence in patients with multiple sclerosis
http://www.cannabis-med.org/studies…ow.php?s_id=185

Nabilone significantly reduces spasticity-related pain
http://www.cannabis-med.org/studies…ow.php?s_id=200

Cannabinoids in multiple sclerosis (CAMS) study
http://www.cannabis-med.org/studies…ow.php?s_id=160

Sativex produced significant improvements in a subjective measure of spasticity
http://www.cannabis-med.org/studies…ow.php?s_id=170

Cannabis-based medicine in central pain in multiple sclerosis.
http://www.cannabis-med.org/studies…ow.php?s_id=175

Do cannabis-based medicinal extracts have general or specific effects
http://www.cannabis-med.org/studies…how.php?s_id=56

Efficacy, safety and tolerability of an oral cannabis extract in the treatment of spasticity
http://www.cannabis-med.org/studies…how.php?s_id=63

cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis.
http://www.cannabis-med.org/studies…how.php?s_id=81

Are oral cannabinoids safe and effective in refractory neuropathic pain?
http://www.cannabis-med.org/studies…ow.php?s_id=143

Dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia
http://www.cannabis-med.org/studies…how.php?s_id=61

Cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis.
http://www.cannabis-med.org/studies…how.php?s_id=82

Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis
http://www.cannabis-med.org/studies…ow.php?s_id=108

Cannabis based medicinal extract on refractory lower urinary tract dysfunction
http://www.cannabis-med.org/studies…ow.php?s_id=103

Analgesic effect of the cannabinoid analogue nabilone
http://www.cannabis-med.org/studies…ow.php?s_id=203

The perceived effects of smoked cannabis on patients with multiple sclerosis.
http://www.cannabis-med.org/studies…how.php?s_id=13

Orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies…how.php?s_id=12

Nabilone in the treatment of multiple sclerosis
http://www.cannabis-med.org/studies…how.php?s_id=11

Effect of cannabinoids on spasticity and ataxia in multiple sclerosis.
http://www.cannabis-med.org/studies…show.php?s_id=2

Delta-9-THC in the treatment of spasticity associated with multiple sclerosis.
http://www.cannabis-med.org/studies…show.php?s_id=1

Tetrahydrocannabinol for tremor in multiple sclerosis.
http://www.cannabis-med.org/studies…show.php?s_id=9

Marihuana as a therapeutic agent for muscle spasm or spasticity
http://www.cannabis-med.org/studies…how.php?s_id=53

Cannabis-based medicine in spasticity caused by multiple sclerosis.
http://www.unboundmedicine.com/medl…tiple_sclerosis

Cannabis based treatments for neuropathic and multiple sclerosis-related pain.
http://www.unboundmedicine.com/medl…is_related_pain

The effect of cannabis on urge incontinence in patients with multiple sclerosis
http://www.unboundmedicine.com/medl…ial__CAMS_LUTS_

Can Cannabis Help Multiple Sclerosis? An International Debate Rages
http://www.pacifier.com/~alive/cmu/…bis_help_ms.htm

Cannabis’ Potential Exciting Researchers in Treatment of ALS, Parkinson’s Disease
http://66.218.69.11/search/cache?ei…&icp=1&.intl=us

The endocannabinoid system is dysregulated in multiple sclerosis
http://brain.oxfordjournals.org/cgi…stract/awm160v1

Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
http://brain.oxfordjournals.org/cgi…ull/126/10/2191

Nabilone

The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies…ow.php?s_id=177

Nabilone versus prochlorperazine
http://www.cannabis-med.org/studies…ow.php?s_id=120

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=123

Antiemetic efficacy of nabilone and alizapride
http://www.cannabis-med.org/studies…ow.php?s_id=127

Nabilone versus domperidone
http://www.cannabis-med.org/studies…ow.php?s_id=129

Comparison of nabilone and prochlorperazine
http://www.cannabis-med.org/studies…ow.php?s_id=128

Nabilone vs. prochlorperazine for refractory emesis
http://www.cannabis-med.org/studies…ow.php?s_id=146

Nabilone vs. placebo
http://www.cannabis-med.org/studies…ow.php?s_id=156

Effects of nabilone and prochlorperazine on chemotherapy-induced emesis
http://www.cannabis-med.org/studies…ow.php?s_id=131

Superiority of nabilone over prochlorperazine
http://www.cannabis-med.org/studies…ow.php?s_id=126

Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children
http://www.cannabis-med.org/studies…ow.php?s_id=120

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=123

Effect of nabilone on nausea and vomiting after total abdominal hysterectomy
http://www.cannabis-med.org/studies…ow.php?s_id=137

Nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies…ow.php?s_id=177

Synthetic cannabinomimetic nabilone on patients with chronic pain
http://www.cannabis-med.org/studies…ow.php?s_id=197

Nabilone significantly reduces spasticity-related pain
http://www.cannabis-med.org/studies…ow.php?s_id=200

Nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson’s disease
http://www.cannabis-med.org/studies…ow.php?s_id=153

Nabilone in the treatment of multiple sclerosis.
http://www.cannabis-med.org/studies…how.php?s_id=11

Nabilone significantly reduces spasticity-related pain
http://www.cannabis-med.org/studies…ow.php?s_id=200

Analgesic effect of the cannabinoid analogue nabilone
http://www.cannabis-med.org/studies…ow.php?s_id=203

Nabilone in the treatment of multiple sclerosis
http://www.cannabis-med.org/studies…how.php?s_id=11

Comparison of nabilone and metoclopramide in the control of radiation-induced nausea.
http://www.cannabis-med.org/studies…ow.php?s_id=130

Nabilone and metoclopramide in the treatment of nausea and vomiting
http://www.cannabis-med.org/studies…ow.php?s_id=121

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=123

Comparison of the antiemetic efficacy of nabilone and alizapride
http://www.cannabis-med.org/studies…ow.php?s_id=127

Nabilone versus domperidone in the treatment of cytotoxic-induced emesis.
http://www.cannabis-med.org/studies…ow.php?s_id=129

Add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain –
http://www.cannabis-med.org/studies…ow.php?s_id=197

Comparison of bronchial effects of nabilone and terbutaline
http://www.cannabis-med.org/studies…how.php?s_id=43

Nabilone Could Treat Chorea and Irritability in Huntington’s Disease
http://neuro.psychiatryonline.org/c…/18/4/553?rss=1

Nausea

THC improves appetite and reverses weight loss in AIDS patients
http://www.cannabis-med.org/studies…ow.php?s_id=189

Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone
http://www.cannabis-med.org/studies…ow.php?s_id=191

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.
http://www.cannabis-med.org/studies…ow.php?s_id=190

Nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies…ow.php?s_id=177

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.
http://www.cannabis-med.org/studies…ow.php?s_id=180

Nausea relieved by tetrahydrocannabinol (dronabinol).
http://www.cannabis-med.org/studies…how.php?s_id=35

An efficient new cannabinoid antiemetic in pediatric oncology.
http://www.cannabis-med.org/studies…show.php?s_id=7

Effect of nabilone on nausea and vomiting after total abdominal hysterectomy.
http://www.cannabis-med.org/studies…ow.php?s_id=137

Marijuana as antiemetic medicine
http://www.cannabis-med.org/studies…ow.php?s_id=134

Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy
http://www.cannabis-med.org/studies…how.php?s_id=31

Inhalation marijuana as an antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=155

Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children
http://www.cannabis-med.org/studies…ow.php?s_id=120

Comparison of nabilone and metoclopramide in the control of radiation-induced nausea.
http://www.cannabis-med.org/studies…ow.php?s_id=130

Nabilone and metoclopramide in the treatment of nausea and vomiting
http://www.cannabis-med.org/studies…ow.php?s_id=121

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=123

Comparison of the antiemetic efficacy of nabilone and alizapride
http://www.cannabis-med.org/studies…ow.php?s_id=127

Nabilone versus domperidone in the treatment of cytotoxic-induced emesis.
http://www.cannabis-med.org/studies…ow.php?s_id=129

THC or Compazine for the cancer chemotherapy patient—the UCLA study
http://www.cannabis-med.org/studies…how.php?s_id=34

Comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=128

Acute and subacute bronchial effects of oral cannabinoids.
http://www.cannabis-med.org/studies…how.php?s_id=44

Nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy.
http://www.cannabis-med.org/studies…ow.php?s_id=146

Nabilone vs. placebo in chemotherapy-induced nausea and vomiting.
http://www.cannabis-med.org/studies…ow.php?s_id=156

Dose vs response of tetrahydroannabinol (THC) vs prochlorperazine
http://www.cannabis-med.org/studies…how.php?s_id=30 delta 9-

Comparative trial of the antiemetic effects of THC and haloperidol
http://www.cannabis-med.org/studies…how.php?s_id=64

Comparison of delta-9-tetrahydrocannabinol and prochlorperazine.
http://www.cannabis-med.org/studies…show.php?s_id=3

Tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications.
http://www.cannabis-med.org/studies…how.php?s_id=88

Antiemetic effect of tetrahydrocannabinol
http://www.cannabis-med.org/studies…show.php?s_id=6

The antiemetic activity of tetrahydrocanabinol versus metoclopramide and thiethylperazine
http://www.cannabis-med.org/studies…how.php?s_id=24

The antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis.
http://www.cannabis-med.org/studies…ow.php?s_id=131

Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy
http://www.cannabis-med.org/studies…show.php?s_id=5

Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate
http://www.cannabis-med.org/studies…how.php?s_id=23

THC as an antiemetic in patients treated with cancer chemotherapy
http://www.cannabis-med.org/studies…how.php?s_id=27

Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-THC.
http://www.cannabis-med.org/studies…ow.php?s_id=107

Superiority of nabilone over prochlorperazine as an antiemetic
http://www.cannabis-med.org/studies…ow.php?s_id=126

Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy.
http://www.cannabis-med.org/studies…show.php?s_id=4

Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids
http://www.unboundmedicine.com/medl…the_least_shrew


Neurons

Marijuana Promotes Neuron Growth
http://www.medpot.net/forums/index.php?showtopic=27460

Marijuana-Like Chemicals in the Brain Calm Neurons
http://www.medpot.net/forums/index.php?showtopic=9686

Marijuana May Spur New Brain Cells
http://www.treatingyourself.com/vbu…read.php?t=5921

Cannabinoids promote embryonic and adult hippocampus neurogenesis
http://www.jci.org/cgi/content/full/115/11/3104

Medical marijuana uses – 700 medical marijuana clinical studies and papers

Neuropathic pain

Cannabinoids Among Most Promising Approaches to Treating Neuropathic Pain
http://www.redorbit.com/news/health…source=r_health

Cannabis-based medicine in central pain in multiple sclerosis
http://www.neurology.org/cgi/conten…t/65/6/812?etoc

Cannabis in painful HIV-associated sensory neuropathy
http://www.cannabis-med.org/studies…ow.php?s_id=199

Smoked cannabis therapy for HIV-related painful peripheral neuropathy
http://www.cannabis-med.org/studies…ow.php?s_id=172

Two cannabis based medicinal extracts for relief of central neuropathic pain
http://www.cannabis-med.org/studies…ow.php?s_id=143

Cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis.
http://www.cannabis-med.org/studies…how.php?s_id=82

Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain
http://www.cannabis-med.org/studies…how.php?s_id=85

Smoked cannabis in painful peripheral neuropathy and cancer pain refractory to opiods.
http://www.cannabis-med.org/studies…how.php?s_id=96

Analgesic effect of the cannabinoid analogue nabilone
http://www.cannabis-med.org/studies…ow.php?s_id=203

The perceived effects of smoked cannabis on patients with multiple sclerosis.
http://www.cannabis-med.org/studies…how.php?s_id=13

Cannabis based treatments for neuropathic and multiple sclerosis-related pain.
http://www.unboundmedicine.com/medl…is_related_pain


Neuroprotectant

Marijuana Protects Your Brain
http://www.roninpub.com/art-mjbrain.html

The neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease
http://www.medscape.com/medline/abstract/17196181

Neuroprotective and Intraocular Pressure-Lowering Effects of (-)Delta-THC
http://www.unboundmedicine.com/medl…del_of_Glaucoma

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol
http://www.unboundmedicine.com/medl…f_peroxynitrite

Neuroprotection induced by Delta(9)-tetrahydrocannabinol in AF5 cells
http://www.unboundmedicine.com/medl…ol_in_AF5_cells

Cannabidiol has a cerebroprotective action
http://www.unboundmedicine.com/medl…iting_mechanism

Cannabidiol but not Delta(9)-THC has a neuroprotective effect without the development of tolerance..
http://www.unboundmedicine.com/medl…nt_of_tolerance

Delta(9)-THC) prevents cerebral infarction
http://www.unboundmedicine.com/medl…ent_hypothermia

Delta(9)-Tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
http://www.unboundmedicine.com/medl…_excitotoxicity

Cannabis and Neuroprotection
http://www.pacifier.com/~alive/cmu/…oprotection.htm

Nutrition

Oily fish makes ’babies brainier’
http://news.bbc.co.uk/2/hi/health/4631006.stm

Efficacy of dietary hempseed oil in patients with atopic dermatitis.
http://www.medscape.com/medline/abs…ryText=hempseed

Effects of smoked marijuana on food intake and body weight
http://www.cannabis-med.org/studies…ow.php?s_id=117

Obesity

Does Cannabis Hold the Key to Treating Cardiometabolic Disease?
http://www.medscape.com/viewarticle/525040_print

Effects of smoked marijuana on food intake and body weight
http://www.cannabis-med.org/studies…ow.php?s_id=117

Osteoporosis

Prototype drug to prevent osteoporosis based on cannabinoids
http://www.news-medical.net/?id=15220

Hebrew U. Researchers Find Cannabis Can Strengthen Bones
http://www.israelnationalnews.com/News/News.aspx/96146

Peripheral cannabinoid receptor, CB2, regulates bone mass
http://www.pnas.org/cgi/content/abstract/103/3/696

New Weapon In Battle Against Osteoporosis
http://www.medicalnewstoday.com/articles/35621.php

Activation of CB2 receptor attenuates bone loss in osteoporosis
http://www.cannabis-med.org/english…el.php?id=210#2

Pain-

Cannabis effective at relieving pain after major surgery
http://www.news-medical.net/?id=17995

Cannabinoids, in combination with (NSAIDS), produce a synergistic analgesic effect
http://www.medjournal.com/forum/sho…587&postcount=1

Cannabinoids Among Most Promising Approaches to Treating Neuropathic Pain,
http://www.redorbit.com/news/health…source=r_health

Cannabinoid analgesia as a potential new therapeutic option
http://www.medscape.com/medline/abstract/16449552

Analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain
http://www.cannabis-med.org/studies…ow.php?s_id=184

Delta-9-THC based monotherapy in fibromyalgia patients
http://www.cannabis-med.org/studies…ow.php?s_id=194

Add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain –
http://www.cannabis-med.org/studies…ow.php?s_id=197

Nabilone significantly reduces spasticity-related pain
http://www.cannabis-med.org/studies…ow.php?s_id=200

Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine.
http://www.cannabis-med.org/studies…ow.php?s_id=178

Are oral cannabinoids safe and effective in refractory neuropathic pain?
http://www.cannabis-med.org/studies…ow.php?s_id=143

Dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia
http://www.cannabis-med.org/studies…how.php?s_id=61

Cannabis use for chronic non-cancer pain
http://www.cannabis-med.org/studies…how.php?s_id=91

Tetrahydrocannabinol for treatment of chronic pain
http://www.cannabis-med.org/studies…ow.php?s_id=147

Analgesic effect of the cannabinoid analogue nabilone
http://www.cannabis-med.org/studies…ow.php?s_id=203

The perceived effects of smoked cannabis on patients with multiple sclerosis.
http://www.cannabis-med.org/studies…how.php?s_id=13

Pain relief with oral cannabinoids in familial Mediterranean fever.
http://www.cannabis-med.org/studies…how.php?s_id=18

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies…how.php?s_id=12

Marihuana as a therapeutic agent for muscle spasm or spasticity.
http://www.cannabis-med.org/studies…how.php?s_id=53

Analgesic effect of delta-9-tetrahydrocannabinol.
http://www.cannabis-med.org/studies…how.php?s_id=16

The analgesic properties of delta-9-tetrahydrocannabinol and codeine.
http://www.cannabis-med.org/studies…how.php?s_id=17

Most pain patients gain benefit from cannabis in a British study
http://www.cannabis-med.org/english…kel.php?id=84#1

Parkinson’s Disease

Marijuana Compounds May Aid Parkinson’s Disease
http://cannabisnews.com/news/19/thread19725.shtml

Marijuana-Like Chemicals Helps Treat Parkinson’s
http://cannabisnews.com/news/22/thread22608.shtml

Cannabis use in Parkinson’s disease: subjective improvement of motor symptoms.
http://www.cannabis-med.org/studies…how.php?s_id=33

Cannabinoids reduce levodopa-induced dyskinesia in Parkinson’s disease
http://www.cannabis-med.org/studies…how.php?s_id=54

Nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson’s disease
http://www.cannabis-med.org/studies…ow.php?s_id=153

Evaluation of cannabidiol in dystonic movement disorders.
http://www.cannabis-med.org/studies…how.php?s_id=14

Beneficial and adverse effects of cannabidiol in a Parkinson patient
http://www.cannabis-med.org/studies…ow.php?s_id=142

Neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease
http://www.medscape.com/medline/abstract/17196181

Post Traumatic Stress Disorder

IDF TO TREAT SHELL SHOCK WITH CANNABIS
http://www.onlinepot.org/medical/id…sshellshock.htm

Study: Marijuana Eases Traumatic Memories
http://cannabisnews.com/news/13/thread13601.shtml

Medical Marijuana: PTSD Medical Malpractice
http://salem-news.com/articles/june…veque_61407.php

Cannabis for the Wounded – Another Walter Reed Scandal
http://www.libertypost.org/cgi-bin/…=179973&Disp=11

PTSD and Cannabis: A Clinician Ponders Mechanism of Action
http://ccrmg.org/journal/06spr/perspective2.html

Cannabis Eases Post Traumatic Stress
http://ccrmg.org/journal/06spr/ptsd.html

Endocannabinoids extinguish bad memories in the brain
http://www.cannabis-med.org/english…el.php?id=123#1

Natural high helps banish bad memories
http://www.newscientist.com/article…d-memories.html

Pregnancy

Oily fish makes ’babies brainier’
http://news.bbc.co.uk/2/hi/health/4631006.stm

Ganja use among Jamaican women.
http://www.rism.org/isg/dlp/ganja/a…anjaBabyes.html

Dreher’s Jamaican Pregnancy Study
http://www.november.org/stayinfo/br…reherStudy.html

Cannabis Relieves Morning Sickness
http://ccrmg.org/journal/06spr/dreher.html#morning

Prenatal Marijuana Exposure and Neonatal Outcomes in Jamaica
http://www.druglibrary.org/Schaffer…/can-babies.htm

The Endocannabinoid-CB Receptor System
http://www.nel.edu/pdf_/25_12/NEL251204A01_Fride_.pdf

CLAIM #7: MARIJUANA USE DURING PREGNANCY HARMS THE FETUS
http://www.erowid.org/plants/cannab…bis_myth7.shtml

Prenatal exposure

Prenatal Marijuana Exposure and Neonatal Outcomes in Jamaica
http://www.druglibrary.org/Schaffer…/can-babies.htm

The Endocannabinoid-CB Receptor System
http://www.nel.edu/pdf_/25_12/NEL251204A01_Fride_.pdf

Ganja use among Jamaican women.
http://www.rism.org/isg/dlp/ganja/a…anjaBabyes.html

Dreher’s Jamaican Pregnancy Study
http://www.november.org/stayinfo/br…reherStudy.html

Nonmutagenic action of cannabinoids in vitro
http://trophort.com/005/993/005993433.html

Prenatal exposure to tobacco, alcohol, cannabis and caffeine on birth size and subsequent growth.
http://www.ncbi.nlm.nih.gov/sites/e…st_uids=3657756

Tobacco and marijuana use on offspring growth from birth through 3 years of age.
http://www.ncbi.nlm.nih.gov/sites/e…Pubmed_RVDocSum

Prenatal marijuana use and neonatal outcome.
http://www.ncbi.nlm.nih.gov/sites/e…Pubmed_RVDocSum

Pruritis

Cream with endocannabinoids effective in the treatment of pruritus
http://bbsnews.net/article.php/20051211212223236/print

Topical cannabinoid agonists : An effective new possibility for treating chronic pruritus.
http://www.cannabis-med.org/studies…ow.php?s_id=196

Dronabinol in patients with intractable pruritus secondary to cholestatic liver disease.
http://www.cannabis-med.org/studies…ow.php?s_id=116

Sativex

Sativex in the treatment of pain caused by rheumatoid arthritis
http://rheumatology.oxfordjournals….bstract/45/1/50

Sativex produced significant improvements in a subjective measure of spasticity
http://www.cannabis-med.org/studies…ow.php?s_id=170

Sativex in patients suffering from multiple sclerosis
http://www.cannabis-med.org/studies…ow.php?s_id=168

Sativex in patients suffering from multiple sclerosis associated detrusor overactivity
http://www.cannabis-med.org/studies…ow.php?s_id=168

Sativex showed positive effects in 65 per cent of patients with chronic diseases
http://www.cannabis-med.org/english…el.php?id=230#4

Schizophrenia/ Mental disorders

Increased cannabinoid receptor density in the posterior cingulate cortex in schizophrenia.
http://www.medscape.com/medline/abstract/16710682

Symptoms of schizotypy precede cannabis use.
http://www.ukcia.org/forum/read.php?7,7543,7579

Cannabidiol as an antipsychotic
http://www.cannabis-med.org/studies…ow.php?s_id=171

Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients
http://www.unboundmedicine.com/medl…of_cannabis_use

Delta-9-Tetrahydrocannabinol-Induced Effects on Psychosis and Cognition
http://www.unboundmedicine.com/medl…s_and_Cognition

Cannabis is a First-Line Treatment for Childhood Mental Disorders
http://www.counterpunch.org/mikuriya07082006.html

Cannabis does not induce schizophrenia,
http://www.medicalnewstoday.com/articles/12283.php

Cannabis use does not cause schizophrenia
http://www.health.am/psy/more/canna…_schizophrenia/

Cannabinoids and psychosis.
http://www.ncbi.nlm.nih.gov/sites/e…Pubmed_RVDocSum

Cannabis as a psychotropic medication
http://bjp.rcpsych.org/cgi/content/full/185/1/78

Study Shows Long Term Marijuana Users Healthy
http://www.erowid.org/plants/cannab…_science3.shtml

Cannabis and schizophrenia link blurs further
http://www.newscientist.com/channel…rs-further.html

Evidence does not show a strong causal relation between the use of cannabis and psychosocial harm
http://www.library.nhs.uk/mentalHea…24106&tabID=289

Sickle Cell Disease

Cannabis Relieves Sickle Cell Disease!
http://www.cannabisculture.com/foru…?Number=1155878

Sickle Cell Disease and Cannabis
http://www.pacifier.com/~alive/cmu/Sickle_cell.htm

Marijuana smoking in young adults with sickle cell
http://caribbean.scielo.org/scielo….&lng=en&nrm=iso

Medical use of cannabis in sickle cell disease
http://www.chanvre-info.ch/info/it/…-in-sickle.html

Cannabis use in sickle cell disease: a questionnaire study.
http://www.ncbi.nlm.nih.gov/sites/e…2&dopt=Abstract

Sleep modulation

Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.
http://www.medscape.com/medline/abs…844117?prt=true

Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension
http://www.cannabis-med.org/studies…ow.php?s_id=181

Cannabis-based medicine in central pain in multiple sclerosis.
http://www.cannabis-med.org/studies…ow.php?s_id=175

Two cannabis based medicinal extracts for relief of central neuropathic pain
http://www.cannabis-med.org/studies…how.php?s_id=15

Functional role for cannabinoids in respiratory stability during sleep
http://www.pacifier.com/~alive/cmu/…sleep_apnea.htm

THC reduces sleep apnoea in animal research
http://www.cannabis-med.org/english…el.php?id=120#1

Spasticity

The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury.
http://www.cannabis-med.org/studies…ow.php?s_id=166

Cannabis-based medicine in spasticity caused by multiple sclerosis
http://www.cannabis-med.org/studies…ow.php?s_id=192

Cannabinoids in multiple sclerosis
http://www.cannabis-med.org/studies…ow.php?s_id=160

Sativex produced significant improvements in a subjective measure of spasticity
http://www.cannabis-med.org/studies…ow.php?s_id=170

Do cannabis-based medicinal extracts have general or specific effects on symptoms in ms?
http://www.cannabis-med.org/studies…how.php?s_id=56

Efficacy, safety and tolerability of an oral cannabis extract in the treatment of spasticity
http://www.cannabis-med.org/studies…how.php?s_id=63

Are oral cannabinoids safe and effective in refractory neuropathic pain?
http://www.cannabis-med.org/studies…ow.php?s_id=143

Experiences with THC-treatment in children and adolescents
http://www.cannabis-med.org/studies…how.php?s_id=80

The treatment of spasticity with D9-THC in patients with spinal cord injury
http://www.cannabis-med.org/studies…how.php?s_id=79

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies…how.php?s_id=12

Nabilone in the treatment of multiple sclerosis.
http://www.cannabis-med.org/studies…how.php?s_id=11

Treatment of spasticity in spinal cord injury with dronabinol
http://www.cannabis-med.org/studies…ow.php?s_id=112

Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects
http://www.cannabis-med.org/studies…how.php?s_id=10

Effect of cannabinoids on spasticity and ataxia in multiple sclerosis.
http://www.cannabis-med.org/studies…show.php?s_id=2

Delta-9-THC in the treatment of spasticity associated with multiple sclerosis.
http://www.cannabis-med.org/studies…show.php?s_id=1

Effect of Delta-9-THC on EMG Measurements in Human Spasticity
http://www.cannabis-med.org/studies…ow.php?s_id=110

The effect of delta-9-THC on human spasticity.
http://www.cannabis-med.org/studies…ow.php?s_id=154

Cannabis effect on spasticity in spinal cord injury.
http://www.cannabis-med.org/studies…ow.php?s_id=113

Treatment of human spasticity with delta 9-tetrahydrocannabinol.
` http://www.cannabis-med.org/studies…show.php?s_id=8

Marihuana as a therapeutic agent for muscle spasm or spasticity.
http://www.cannabis-med.org/studies…how.php?s_id=53

The perceived effects of marijuana on spinal cord injured males.
http://www.cannabis-med.org/studies…ow.php?s_id=138

Motor effects of delta 9 THC in cerebellar Lurcher mutant mice.
http://www.unboundmedicine.com/medl…her_mutant_mice

Cannabis-based medicine in spasticity caused by multiple sclerosis
http://www.unboundmedicine.com/medl…tiple_sclerosis

Spinal Cord Injury

The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury http://www.cannabis-med.org/studies…ow.php?s_id=166

Are oral cannabinoids safe and effective in refractory neuropathic pain?
http://www.cannabis-med.org/studies…ow.php?s_id=143

The treatment of spasticity with D9-THC) in patients with spinal cord injury
http://www.cannabis-med.org/studies…how.php?s_id=79

Delta-9-THC as an alternative therapy for overactive bladders in spinal cord injury
http://www.cannabis-med.org/studies…ow.php?s_id=102

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies…how.php?s_id=12

Treatment of spasticity in spinal cord injury with dronabinol
http://www.cannabis-med.org/studies…ow.php?s_id=112

Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects
http://www.cannabis-med.org/studies…how.php?s_id=10

The effect of delta-9-THC on human spasticity
http://www.cannabis-med.org/studies…ow.php?s_id=154

Cannabis effect on spasticity in spinal cord injury
http://www.cannabis-med.org/studies…ow.php?s_id=113

Marihuana as a therapeutic agent for muscle spasm or spasticity
http://www.cannabis-med.org/studies…how.php?s_id=53

The perceived effects of marijuana on spinal cord injured males
http://www.cannabis-med.org/studies…ow.php?s_id=138

Stroke

Cannabidiol has a cerebroprotective action
http://www.unboundmedicine.com/medl…iting_mechanism

Delta(9)-THC) prevents cerebral infarction
http://www.unboundmedicine.com/medl…ent_hypothermia

Medical marijuana: study shows that THC slows atherosclerosis
http://thenexthurrah.typepad.com/th…al_marijua.html


Tea as medicine

Cannabis tea revisited: A systematic evaluation
http://www.ncbi.nlm.nih.gov/sites/e…Pubmed_RVDocSum

THC/tetrahydrocannabinol

THC is effective in the treatment of tics in Tourette syndrome
http://www.cannabis-med.org/studies…how.php?s_id=98

THC effective in Tourette-Syndrome
http://www.pacifier.com/~alive/cmu/tourette_thc.htm

THC effective in Tourette syndrome in a 6-week trial
http://www.cannabis-med.org/english…el.php?id=146#1

Treatment of Tourette’s Syndrome With Delta-9-Tetrahydrocannabinol
http://ajp.psychiatryonline.org/cgi…/full/156/3/495

THC inhibits primary marker of Alzheimer’s disease
http://www.cannabis-med.org/english…el.php?id=225#3

THC improves appetite and reverses weight loss in AIDS patients
http://www.cannabis-med.org/studies…ow.php?s_id=189

Cancer-related anorexia-cachexia syndrome
http://www.unboundmedicine.com/medl…xia_Study_Group

THC effective in appetite and weight loss in severe lung disease (COPD)
http://www.cannabis-med.org/english…el.php?id=191#2

The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat
http://www.unboundmedicine.com/medl…binoid_receptor

Synergy between Delta(9)-tetrahydrocannabinol and morphine in the arthritic rat
http://www.unboundmedicine.com/medl…e_arthritic_rat

Bronchial effects of aerosolized delta 9-tetrahydrocannabinol
http://www.cannabis-med.org/studies…ow.php?s_id=109

Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol
http://www.cannabis-med.org/studies…how.php?s_id=60

Effects of smoked marijuana in experimentally induced asthma
http://www.cannabis-med.org/studies…how.php?s_id=57

Marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance
http://www.cannabis-med.org/studies…how.php?s_id=67

New Synthetic Delta-9-THC Inhaler Offers Safe, Rapid Delivery
http://www.medicalnewstoday.com/articles/22937.php

Smoked marijuana and oral delta-9-THC on specific airway conductance in asthmatic subjects
http://www.ukcia.org/research/Smoke…InAsthmatic.php

Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
http://www.cannabis-med.org/studies…ow.php?s_id=193

9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer
http://cancerres.aacrjournals.org/c…ract/66/13/6615

THC and prochlorperazine effective in reducing vomiting in women following breast surgery
http://www.cannabis-med.org/english…el.php?id=219#1

Delta9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells
http://mcr.aacrjournals.org/cgi/con…bstract/4/8/549

Delta(9)-THC) prevents cerebral infarction
http://www.unboundmedicine.com/medl…ent_hypothermia

Medical marijuana: study shows that THC slows atherosclerosis
http://thenexthurrah.typepad.com/th…al_marijua.html

Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects
http://www.cannabis-med.org/studies…how.php?s_id=10

The effect of delta-9-THC on human spasticity
http://www.cannabis-med.org/studies…ow.php?s_id=154

The treatment of spasticity with D9-THC) in patients with spinal cord injury
http://www.cannabis-med.org/studies…how.php?s_id=79

Delta-9-THC as an alternative therapy for overactive bladders in spinal cord injury
http://www.cannabis-med.org/studies…ow.php?s_id=102

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies…how.php?s_id=12

The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury
http://www.cannabis-med.org/studies…ow.php?s_id=166

Delta-9-Tetrahydrocannabinol-Induced Effects on Psychosis and Cognition
http://www.unboundmedicine.com/medl…s_and_Cognition

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies…how.php?s_id=12

Marihuana as a therapeutic agent for muscle spasm or spasticity
http://www.cannabis-med.org/studies…how.php?s_id=53

Analgesic effect of delta-9-tetrahydrocannabinol
http://www.cannabis-med.org/studies…how.php?s_id=16

The analgesic properties of delta-9-tetrahydrocannabinol and codeine
http://www.cannabis-med.org/studies…how.php?s_id=17

The perceived effects of smoked cannabis on patients with multiple sclerosis
http://www.cannabis-med.org/studies…how.php?s_id=13

Cannabis use for chronic non-cancer pain
http://www.cannabis-med.org/studies…how.php?s_id=91

Tetrahydrocannabinol for treatment of chronic pain
http://www.cannabis-med.org/studies…ow.php?s_id=147

Delta-9-THC based monotherapy in fibromyalgia patients
http://www.cannabis-med.org/studies…ow.php?s_id=194

Delta(9)-THC) prevents cerebral infarction
http://www.unboundmedicine.com/medl…ent_hypothermia

Delta(9)-Tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
http://www.unboundmedicine.com/medl…_excitotoxicity

Tobacco vs Cannabis-

Cannabis Smoke and Cancer: Assessing the Risk
http://www.norml.org/index.cfm?Group_ID=6891

Cannabis and tobacco smoke are not equally carcinogenic
http://www.pubmedcentral.nih.gov/ar…i?artid=1277837

Smoking Marijuana Does Not Cause Lung Cancer
http://www.mapinc.org/drugnews/v05/n1065/a03.html

Tobacco and marijuana use on offspring growth from birth through 3 years of age
http://www.ncbi.nlm.nih.gov/sites/e…Pubmed_RVDocSum

Progression from marijuana use to daily smoking and nicotine dependence
http://www.erowid.org/references/refs_view.php?ID=6951

High anxieties – What the WHO doesn’t want you to know about cannabis
http://www.newscientist.com/article…t-cannabis.html

Radioactive tobacco
http://www.cannabisculture.com/news/tobacco/

Tourette’s Syndrome

Treatment of Tourette’s Syndrome With Delta-9-Tetrahydrocannabinol
http://ajp.psychiatryonline.org/cgi…/full/156/3/495

THC is effective in the treatment of tics in Tourette syndrome
http://www.cannabis-med.org/studies…how.php?s_id=98

Treatment of Tourette’s syndrome with Delta 9-tetrahydrocannabinol
http://www.cannabis-med.org/studies…how.php?s_id=99

Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome
http://www.cannabis-med.org/studies…ow.php?s_id=100

THC effective in Tourette-Syndrome
http://www.pacifier.com/~alive/cmu/tourette_thc.htm

THC effective in Tourette syndrome in a 6-week trial
http://www.cannabis-med.org/english…el.php?id=146#1

Vaporizers

Vaporization as a smokeless cannabis delivery system
http://www.cannabis-med.org/studies…ow.php?s_id=187

Smokeless Cannabis Delivery Device Efficient And Less Toxic
http://www.medicalnewstoday.com/articles/71112.php

Volcano is to Vaporizer As Porsche is to Automobile
http://ccrmg.org/journal/04spr/volcano.html

Recommendation to Patients: “Don’t smoke, Vaporize”
http://ccrmg.org/journal/03sum/vaporize.html

Decreased respiratory symptoms in cannabis users who vaporize
http://marijuana.researchtoday.net/archive/4/4/1195.htm

Use of vaporizers reduces toxins from cannabis smoke
http://www.cannabis-med.org/english…el.php?id=146#2

Wilson’s Disease

Cannabis sativa and dystonia secondary to Wilson’s disease
http://www.medscape.com/medline/abstract/15390041

 

Shocking connection: 97% of all terminal cancer patients previously had a root canal procedure…

 Do you have a chronic degenerative disease? If so, have you been told, “It’s all in your head?” Well, that might not be that far from the truth… the root cause of your illness may be in your mouth.

There is a common dental procedure that nearly every dentist will tell you is completely safe, despite the fact that scientists have been warning of its dangers for more than 100 years. Every day in the United States alone, 41,000 of these dental procedures are performed on patients who believe they are safely and permanently fixing their problem.

What is this dental procedure?

The root canal. More than 25 million root canals are performed every year in this country.


Root-canaled teeth are essentially “dead” teeth that can become silent incubators for highly toxic anaerobic bacteria that can, under certain conditions, make their way into your bloodstream to cause a number of serious medical conditions—many not appearing until decades later.

Most of these toxic teeth feel and look fine for many years, which make their role in systemic disease even harder to trace back.

Sadly, the vast majority of dentists are oblivious to the serious potential health risks they are exposing their patients to, risks that persist for the rest of their patients’ lives. The American Dental Association claims root canals have been proven safe, but they have NO published data or actual research to substantiate this claim.

Fortunately, I had some early mentors like Dr. Tom Stone and Dr. Douglas Cook, who educated me on this issue nearly 20 years ago. Were it not for a brilliant pioneering dentist who, more than a century ago, made the connection between root-canaled teeth and disease, this underlying cause of disease may have remained hidden to this day. The dentist’s name was Weston Price — regarded by many as the greatest dentist of all time.

Weston A. Price: World’s Greatest Dentist

Most dentists would be doing an enormous service to public health if they familiarized themselves with the work of Dr. Weston Pricei. Unfortunately, his work continues to be discounted and suppressed by medical and dental professionals alike.

Dr. Price was a dentist and researcher who traveled the world to study the teeth, bones, and diets of native populations living without the “benefit” of modern food. Around the year 1900, Price had been treating persistent root canal infections and became suspicious that root-canaled teeth always remained infected, in spite of treatments. Then one day, he recommended to a woman, wheelchair bound for six years, to have her root canal tooth extracted, even though it appeared to be fine.

She agreed, so he extracted her tooth and then implanted it under the skin of a rabbit. The rabbit amazingly developed the same crippling arthritis as the woman and died from the infection 10 days later. But the woman, now free of the toxic tooth, immediately recovered from her arthritis and could now walk without even the assistance of a cane.

Price discovered that it’s mechanically impossible to sterilize a root-canaled (e.g. root-filled) tooth.

He then went on to show that many chronic degenerative diseases originate from root-filled teeth—the most frequent being heart and circulatory diseases. He actually found 16 different causative bacterial agents for these conditions. But there were also strong correlations between root-filled teeth and diseases of the joints, brain and nervous system.

Dr. Price went on to write two groundbreaking books in 1922 detailing his research into the link between dental pathology and chronic illness. Unfortunately, his work was deliberately buried for 70 years, until finally one endodontist named George Meinig recognized the importance of Price’s work and sought to expose the truth.

Must-read book on the subject: The Secret Poison in Your Mouth: Banish the Hidden Cause of Cancer, Heart Disease and Arthritis;

Dr. Meinig advances the work of Dr. Price

Dr. Meinig, a native of Chicago, was a captain in the U.S. Army during World War II before moving to Hollywood to become a dentist for the stars. He eventually became one of the founding members of the American Association of Endodontists (root canal specialists).

In the 1990s, he spent 18 months immersed in Dr. Price’s research. In June of 1993, Dr. Meinig published the book Root Canal Cover-Up, which continues to be the most comprehensive reference on this topic today. You can order your copy directly from the Price-Pottenger Foundation. ii

What dentists don’t know about the anatomy of your teeth

Your teeth are made of the hardest substances in your body.

In the middle of each tooth is the pulp chamber, a soft living inner structure that houses blood vessels and nerves. Surrounding the pulp chamber is the dentin, which is made of living cells that secrete a hard mineral substance. The outermost and hardest layer of your tooth is the white enamel, which encases the dentin.

The roots of each tooth descend into your jawbone and are held in place by the periodontal ligament. In dental school, dentists are taught that each tooth has one to four major canals. However, there are accessory canals that are never mentioned. Literally miles of them!

Just as your body has large blood vessels that branch down into very small capillaries, each of your teeth has a maze of very tiny tubules that, if stretched out, would extend for three miles. Weston Price identified as many as 75 separate accessory canals in a single central incisor (front tooth). For a more detailed explanation, refer to an article by Hal Huggins, DDS, MS, on the Weston A. Price Foundation website.iii (These images are borrowed from the Huggins article.)

Microscopic organisms regularly move in and around these tubules, like gophers in underground tunnels.

When a dentist performs a root canal, he or she hollows out the tooth, then fills the hollow chamber with a substance (called guttapercha), which cuts off the tooth from its blood supply, so fluid can no longer circulate through the tooth. But the maze of tiny tubules remains. And bacteria, cut off from their food supply, hide out in these tunnels where they are remarkably safe from antibiotics and your own body’s immune defenses.

The root cause of much disease

Under the stresses of oxygen and nutrient deprivation, these formerly friendly organisms morph into stronger, more virulent anaerobes that produce a variety of potent toxins. What were once ordinary, friendly oral bacteria mutate into highly toxic pathogens lurking in the tubules of the dead tooth, just awaiting an opportunity to spread.

No amount of sterilization has been found effective in reaching these tubules — and just about every single root-canaled tooth has been found colonized by these bacteria, especially around the apex and in the periodontal ligament. Oftentimes, the infection extends down into the jawbone where it creates cavitations — areas of necrotic tissue in the jawbone itself.

Cavitations are areas of unhealed bone, often accompanied by pockets of infected tissue and gangrene. Sometimes they form after a tooth extraction (such as a wisdom tooth extraction), but they can also follow a root canal. According to Weston Price Foundation, in the records of 5,000 surgical cavitation cleanings, only two were found healed.

And all of this occurs with few, if any, accompanying symptoms. So you may have an abscessed dead tooth and not know it. This focal infection in the immediate area of the root-canaled tooth is bad enough, but the damage doesn’t stop there.

Root canals can lead to heart, kidney, bone, and brain disease

As long as your immune system remains strong, any bacteria that stray away from the infected tooth are captured and destroyed. But once your immune system is weakened by something like an accident or illness or other trauma, your immune system may be unable to keep the infection in check.

These bacteria can migrate out into surrounding tissues by hitching a ride into your blood stream, where they are transported to new locations to set up camp. The new location can be any organ or gland or tissue.

Dr. Price was able to transfer diseases harbored by humans to rabbits, by implanting fragments of root-canaled teeth, as mentioned above. He found that root canal fragments from a person who had suffered a heart attack, when implanted into a rabbit, would cause a heart attack in the rabbit within a few weeks.

He discovered he could transfer heart disease to the rabbit 100 percent of the time! Other diseases were more than 80 percent transferable by this method. Nearly every chronic degenerative disease has been linked with root canals, including:

– Heart disease
– Kidney disease
– Arthritis, joint, and rheumatic diseases
– Neurological diseases (including ALS and MS)
– Autoimmune diseases (Lupus and more)

There may also be a cancer connection. Dr. Robert Jones, a researcher of therelationship between root canals and breast cancer, found an extremely high correlation between root canals and breast cancer.iv He claims to have found the following correlations in a five-year study of 300 breast cancer cases:

-93 percent of women with breast cancer had root canals
-7 percent had other oral pathology
-Tumors, in the majority of cases, occurred on the same side of the body as the root canal(s) or other oral pathology

Dr. Jones claims that toxins from the bacteria in an infected tooth or jawbone are able to inhibit the proteins that suppress tumor development. A German physician reported similar findings. Dr. Josef Issels reported that, in his 40 years of treating “terminal” cancer patients, 97 percent of his cancer patients had root canals. If these physicians are correct, the cure for cancer may be as simple as having a tooth pulled, then rebuilding your immune system.

Good bugs gone bad

How are these mutant oral bacteria connected with heart disease or arthritis? The ADA and the AAE claim it’s a “myth” that the bacteria found in and around root-canaled teeth can cause diseasev. But they base that on the misguided assumption that the bacteria in these diseased teeth are the SAME as normal bacteria in your mouth — and that’s clearly not the case.

Today, bacteria can be identified using DNA analysis, whether they’re dead or alive, from their telltale DNA signatures.

In a continuation of Dr. Price’s work, the Toxic Element Research Foundation (TERF) used DNA analysis to examine root-canaled teeth, and they found bacterial contamination in 100 percent of the samples tested. They identified 42 different species of anaerobic bacteria in 43 root canal samples. In cavitations, 67 different bacteria were identified among the 85 samples tested, with individual samples housing between 19 to 53 types of bacteria each. The bacteria they found included the following types:

– Capnocytophagaochracea
– Fusobacteriumnucleatum
– Gemellamorbillorum
– Leptotrichiabuccalis
– Porphyromonasgingivalis

Are these just benign, ordinary mouth bugs? Absolutely not. Four can affect your heart, three can affect your nerves, two can affect your kidneys, two can affect your brain, and one can infect your sinus cavities… so they are anything BUT friendly! (If you want see just how unfriendly they can be, I invite you to investigate the footnotes.)

Approximately 400 percent more bacteria were found in the blood surrounding the root canal tooth than were found in the tooth itself, suggesting the tooth is the incubatorand the periodontal ligament is the food supply. The bone surrounding root-canaled teeth was found even HIGHER in bacterial count… not surprising, since bone is virtual buffet of bacterial nutrients.

Since when is leaving a dead body part IN your body a good idea?

There is no other medical procedure that involves allowing a dead body part to remain in your body. When your appendix dies, it’s removed. If you get frostbite or gangrene on a finger or toe, it is amputated. If a baby dies in utero, the body typically initiates a miscarriage.

Your immune system doesn’t care for dead substances, and just the presence of dead tissue can cause your system to launch an attack, which is another reason to avoid root canals — they leave behind a dead tooth.

Infection, plus the autoimmune rejection reaction, causes more bacteria to collect around the dead tissue. In the case of a root canal, bacteria are given the opportunity to flush into your blood stream every time you bite down.

Why dentists cling to the belief root canals are safe

The ADA rejects Dr. Price’s evidence, claiming root canals are safe, yet they offer no published data or actual research to substantiate their claim. American Heart Association recommends a dose of antibiotics before many routine dental procedures to prevent infective endocarditis (IE) if you have certain heart conditions that predispose you to this type of infection.

So, on the one hand, the ADA acknowledges oral bacteria can make their way from your mouth to your heart and cause a life-threatening infection.

But at the same time, the industry vehemently denies any possibility that these same bacteria—toxic strains KNOWN to be pathogenic to humans — can hide out in your dead root-canaled tooth to be released into your blood stream every time you chew, where they can damage your health in a multitude of ways.

Is this really that large of a leap? Could there be another reason so many dentists, as well as the ADA and the AAE, refuse to admit root canals are dangerous? Well, yes, as a matter of fact, there is. Root canals are the most profitable procedure in dentistry.

What you need to know to AVOID a root canal

I strongly recommend never getting a root canal. Risking your health to preserve a tooth simply doesn’t make sense. Unfortunately, there are many people who’ve already have one. If you have, you should seriously consider having the tooth removed, even if it looks and feels fine.

Remember, as soon as your immune system is compromised, your risk of of developing a serious medical problem increases — and assaults on your immune system are far too frequent in today’s world.

If you have a tooth removed, there are a few options available to you.

1) Partial denture: This is a removable denture, often just called a “partial.” It’s the simplest and least expensive option.
2) Bridge: This is a more permanent fixture resembling a real tooth but is a bit more involved and expensive to build.
3) Implant: This is a permanent artificial tooth, typically titanium, implanted in your gums and jaw. There are some problems with these due to reactions to the metals used. Zirconium is a newer implant material that shows promise for fewer complications.

But just pulling the tooth and inserting some sort of artificial replacement isn’t enough.

Dentists are taught to remove the tooth but leave your periodontal ligament. But as you now know, this ligament can serve as a breeding ground for deadly bacteria. Most experts who’ve studied this recommend removing the ligament, along with one millimeter of the bony socket, in order to drastically reduce your risk of developing an infection from the bacterially infected tissues left behind.

I strongly recommend consulting a biological dentist because they are uniquely trained to do these extractions properly and safely, as well as being adept at removing mercury fillings, if necessary. Their approach to dental care is far more holistic and considers the impact on your entire body — not JUST your mouth.

If you need to find a biological dentist in your area, I recommend visiting toxicteeth.org, a resource sponsored by Consumers for Dental Choice. This organization, championed by Charlie Brown, is a highly reputable organization that has fought to protect and educate consumers so that they can make better-informed decisions about their dental care. The organization also heads up the Campaign for Mercury-Free Dentistry.

Must-read book on the subject: The Secret Poison in Your Mouth: Banish the Hidden Cause of Cancer, Heart Disease and Arthritis;

By Dr. Joseph Mercola

From the author: The existing medical establishment is responsible for killing and permanently injuring millions of Americans, but the surging numbers of visitors to Mercola.com since I began the site in 1997 – we are now routinely among the top 10 health sites on the Internet – convinces me that you, too, are fed up with their deception. You want practical health solutions without the hype, and that’s what I offer.

References:
i Weston A. Price Foundation
ii Price-Pottenger Foundation
iii Weston A. Price Foundation June 25, 2010
iv Quantum Cancer Management
v American Association of Endodontists
vi Journal of Clinical Microbiology February 2007
vii Journal of Clinical Microbiology July 2003
viii Clinical Infectious Diseases June 1996
ix Science Daily January 4, 2011
x The Wealthy Dentist July 12, 2011
xi ToxicTeeth.org

Dandelion root makes cancer cells disintegrate within 48 hours

The Plant That Everyone Has, But Nobody Knows about; Dandelion root Makes Cancer Cells Disintegrate Within 48 Hours

Quick – what’s the best use for dandelions? If you’re like most people, you probably can’t think of an answer, or maybe think of dandelion wine – but we’re here to tell you it’s something much, much better!

DandelionIt turns out dandelions are actually really effective at fighting cancer. Pretty cool, right?

Researchers at the University of Windsor in Ontario have shown that dandelion root extract can cause human melanoma cells to essentially kill themselves without leading to any type of toxicity. In fact, their initial study saw cancer cells disintegrating within 48 hours, while healthy cells remained unaffected. The study was led by Professor Siyaram Pandey, PhD.

These promising results prompted the non-profit organization Mitacs to reach out to AOR Inc., a Calgary company that produces natural health products, in order to develop a dandelion tea powder that is significantly stronger than that found in health food stores. They accomplish this by milling dandelion root, creating an extract from it, and then freeze-drying it into a powder that patients dissolve into hot water and then drink.

AOR is producing 6,000 doses of this tea for a clinical trial that will take place at the Windsor Regional Cancer Centre, and will involve 30 patients with various types of cancer, including leukemia, who have not had success with conventional therapy.

Dandelion Root Project

A statement on the website of the Dandelion Root Project at the University of Windsor says:Since the commencement of this project, we have been able to successfully assess the effect of a simple water extract of dandelion root in various human cancer cell types, in the lab and we have observed its effectiveness against human T cell leukemia, chronic myelomonocytic leukemia, pancreatic and colon cancers, with no toxicity to non-cancer cells. Furthermore, these efficacy studies have been confirmed in animal models (mice) that have been transplanted with human colon cancer cells.

Researcher and medical oncologist Dr. Caroline Hamm said that some of her patients have noted improvements after drinking dandelion root tea from health food stores. The concentrated tea could prove to be even more effective, potentially saving countless lives.

A 2008 study published in the International Journal of Oncology showed that dandelion tea reduced breast and prostate cancer cells. A subsequent report in the same journal showed that a dietary supplement that contained dandelion suppressed the growth of prostate cancer cells. Dandelion extracts have also demonstrated their efficacy in treating breast cancer and leukemia in traditional Chinese medicine as well as in Native American medicine.

How Does it Work?

Get your Tachyonized Dandelion Tonic here

This extract causes cancer cells to go through apoptosis, a natural cell process where a cell activates an intracellular death program because it isn`t needed anymore. In brief, dandelion root extract causes the cancer cell to “commit suicide” without affecting the healthy ones.

Two cells perform apoptosis which is far better than chemotherapy drugs which kill one healthy cell for every 5 to 10 cancer cell, the dandelion extract.

It is important to mention that the concentration of this extract is much higher than the one which is currently available. Even though trials are still underway, this extract may be the future of cancer treatment!If you would like to learn more about this, check out the following video. Dr. Siyaram Pandey’s explains how dandelion root causes the death of cancer cells within 24 hours.

Get your Tachyonized Dandelion Tonic here

@2017 Native American’s.

Source: The Plant That Everyone Has, But Nobody Knows That it Makes Cancer Cells Disintegrate Within 48 Hours

Intra-Lesional Injection of the Novel PKC Activator EBC-46 Rapidly Ablates Tumors in Mouse Models

Abstract

Intra-lesional chemotherapy for treatment of cutaneous malignancies has been used for many decades, allowing higher local drug concentrations and less toxicity than systemic agents. Here we describe a novel diterpene ester, EBC-46, and provide preclinical data supporting its use as an intra-lesional treatment. A single injection of EBC-46 caused rapid inflammation and influx of blood, followed by eschar formation and rapid tumor ablation in a range of syngeneic and xenograft models. EBC-46 induced oxidative burst from purified human polymorphonuclear cells, which was prevented by the Protein Kinase C inhibitor bisindolylmaleimide-1. EBC-46 activated a more specific subset of PKC isoforms (PKC-βI, -βII, -α and -γ) compared to the structurally related phorbol 12-myristate 13-acetate (PMA). Although EBC-46 showed threefold less potency for inhibiting cell growth than PMA in vitro, it was more effective for cure of tumors in vivo. No viable tumor cells were evident four hours after injection by ex vivo culture. Pharmacokinetic profiles from treated mice indicated that EBC-46 was retained preferentially within the tumor, and resulted in significantly greater local responses (erythema, oedema) following intra-lesional injection compared with injection into normal skin. The efficacy of EBC-46 was reduced by co-injection with bisindolylmaleimide-1. Loss of vascular integrity following treatment was demonstrated by an increased permeability of endothelial cell monolayers in vitro and by CD31 immunostaining of treated tumors in vivo. Our results demonstrate that a single intra-lesional injection of EBC-46 causes PKC-dependent hemorrhagic necrosis, rapid tumor cell death and ultimate cure of solid tumors in pre-clinical models of cancer.

Glen M. Boyle,#1,* Marjorie M. A. D’Souza,#1,2 Carly J. Pierce,1 Ryan A. Adams,1,2,3 Aaron S. Cantor,1 Jenny P. Johns,1 Lidia Maslovskaya,1 Victoria A. Gordon,4 Paul W. Reddell,4 and Peter G. Parsons1
Qiming Jane Wang, Editor
Author information ► Article notes ► Copyright and License information ►

Introduction

Surgical excision and ionizing radiation of affected sites have been the mainstay for treatment of cancer patients for decades. Whilst often effective, efficacy of these treatments can be limited by various factors including the condition of the patient, the proximity of adjacent vital tissues, inaccessibility of the tumor and intolerance of normal tissue for repeated courses of treatment. In some of these cases, intra-tumoral treatment may be more appropriate, particularly when surgical intervention is not possible. There have therefore been many attempts to deliver localized therapies, such as injection of anti-cancer agents [1]–[3] and lethal implants [4], aiming for palliation or even cure. Intra-tumoral treatment may have the advantage of allowing for much higher drug concentrations at the tumor site, and potentially less toxicity than systemic agents. However, a limiting factor for greater use of intra-tumoral treatments appears to be lack of suitable agents rather than delivery technologies.

The protein kinase C (PKC) family are ubiquitous serine-threonine kinases found in many cell types that translocate to membranes after activation and regulate diverse downstream processes, like proliferation, apoptosis, differentiation, and migration. There are ten main human isoforms that comprise three subgroups divided according to sequence homology and cofactor requirements. The classical PKC subgroup includes -α, -βI and-βII (alternatively spliced from the same gene), and -γ, which require binding of calcium and DAG to activate the enzyme. Members of the novel PKC subgroup include -δ, -ε, -η and -θ, which require DAG for activation but are calcium-independent. The atypical PKCs, -ι and -ζ, are independent of calcium and DAG, but have been shown to be activated by distinct lipids and protein-protein interactions [5], [6].

Inhibition of PKC signaling has been targeted as an anti-cancer treatment as PKC isozymes are known to play roles in cellular proliferation and vasculature formation [7]–[9], important for tumor growth. However, several clinical trials performed with compounds thought to inhibit PKC signaling have had disappointing results [9]. For example, enzastaurin, an orally available specific inhibitor of PKC-β, showed limited efficacy as a single agent in Phase II studies of advanced diffuse large B-cell lymphoma or non-small cell lung cancer [10], [11]. Clinical trials of enzastaurin with additional chemotherapy agents are underway.

In contrast, previous work has shown that intravenous administration of the prototypic PKC activating compound phorbol 12-myristate 13-acetate (PMA) to patients suffering from myleocytic malignancies resistant to chemotherapy resulted in remission [12], [13]. We have previously demonstrated that three topical applications of the PKC-activating ingenol ester PEP005 (ingenol mebutate or ingenol 3-angelate) are sufficient for enduring regression of skin cancer lesions (including melanoma) in pre-clinical models [14], [15]. PEP005 has recently been approved for topical treatment of actinic keratoses [16], [17], and shows efficacy in additional models of squamous cell carcinoma [18], [19]. We now describe a novel PKC-activating compound, EBC-46, and demonstrate that a single intra-lesional injection is sufficient for enduring regression and ultimate cure of diverse tumor types in pre-clinical models of cancer.

Materials and Methods

Reagents

EBC-46 was purified from the kernels of the fruit from Fontainea picrosperma, was provided by QBiotics Ltd. (Yungaburra, Queensland) at greater than 97% purity. Phorbol 12-myristate 13-acetate (PMA), dihydroethidium and bisindolylmaleimide-1 (BIS-1) were purchased from Sigma (St. Louis, MO).

Cell lines

All cell lines used in this study were purchased from ATCC (SK-MEL-28, B16-F0, HeLa, FaDu, MCF-7, HT-29) except MC-38 [20], [21] and MM649 [22] cells, which were described previously. Cell lines were grown in complete media (RPMI-1640 supplemented with 10% heat-inactivated fetal calf serum, 3 mM HEPES, 100 U/ml penicillin and 100 µg/ml streptomycin (CSL Ltd, Melbourne, Australia)). Cells were routinely checked by STR profiling, and for mycoplasma infection by Hoechst staining [23] and PCR, and were always negative.

Human ethics statement

This study was performed in strict accordance with the recommendations in the Australian National Statement on Ethical Conduct in Human Research (2007 – Updated December 2013), of the National Health and Medical Research Council of Australia. All protocols were reviewed and approved by the QIMR Berghofer Medical Research Institute Human Research Ethics Committee (QIMR-HREC), approval number P764. All participants provided written informed consent to donate their blood samples for research.

Measurement of reactive oxygen species production in PMN cells

PMN cells were isolated from peripheral blood from healthy volunteers. Aliquots of 2×106 PMN cells were stained incubated for 15 min at 37°C with 10 µg/ml dihydroethidium (DHE). 2×106 unstained PMN cells were incubated at 37°C to act as an unstained control. Where appropriate, PMN cells were also incubated with 1 µM bisindolylmaleimide-1. The stained PMN cells were treated with the either PMA or EBC-46 for 15 min, and the change in fluorescence resulting from oxidation of DHE to ethidium bromide measured on a dual beam FACSCalibur (BD Biosciences, Franklin Lakes, NJ) using CellQuest Pro (BD Biosciences) software.

PKC-EGFP translocation

pPKC-α, -βII, -γ, -θ and –ζ-EGFP were purchased from Clontech (Moutain View, CA). pPKC-βI, -δ, -ε, -η and -ι-EGFP were constructed in-house. PKC isoforms were cloned from Universal Human Tumor cDNA (Life Technologies, Carlsbad, CA) and ligated into pPKC-ζ-EGFP digested with XhoI/SacII. The identity and fidelity of all PKC isoforms was verified by Sanger sequencing. 96-well plates were seeded with 3×104 cells/well of SK-MEL-28 in complete media, and incubated at 37°C, 5% CO2, and 95% humidity. After 24 h, cells were transiently transfected with a 1∶3 ratio of pPKC-EGFP vector DNA: Lipofectamine 2000 (Life Technologies) (0.16 µg DNA: 0.48 µl Lipofectamine per well) in Opti-MEM media (Life Technologies). After 24 h incubation, cells were washed with phosphate-buffered saline (PBS) and treated with 100 ng/ml of either PMA or EBC-46 for 1 h. Cells were washed twice with ice-cold PBS, fixed with 2% formaldehyde/0.2% gluteraldehyde in PBS, washed twice again with ice-cold PBS, and overlaid with 100 µl of PBS. Fluorescent cells were examined with an AMG EvosFl (Life Technologies) inverted fluorescence microscope at 40×. Micrographs were taken such that at least 50 fluorescent cells/well were captured, and transmitted light images were overlaid with fluorescence images for control wells to calculate transfection efficiency. Cells were counted in each image using ImageJ (NIH) and classified according to the localization of fluorescence as cytoplasmic, plasma membrane, perinuclear membrane, or other membrane (mitochondria, endoplasmic reticulum, Golgi apparatus, or unknown). A total of three independent experiments were performed for each PKC isoform.

Immunofluorescence

HeLa cells were treated with either 175 nM (100 ng/ml) PMA or EBC-46, or vehicle alone for 1 h. PKC-α (Cat. No. 2056; Cell Signaling Technologies) was detected by immunofluorescence as described by the manufacturer. Images were acquired using a Leica TCS Inverted Fluoresence Microscope with a Nikon DS-Fi1C camera.

PKC kinase assay

HeLa cells were treated with 175 nM (100 ng/ml) or 17.5 µM (10 µg/ml) of either PMA or EBC-46 for 1 h. Cells were lysed and stored at −80°C, before the level of PKC-specific kinase activity was measured in 30 µg HeLa lysate using the PKC Kinase Activity Assay Kit (AbCam, Cambridge, U.K.; Cat. No. ab139437) as described by the manufacturer. Assays were performed in triplicate with the mean ± SD shown.

Cell growth assay

Cells were seeded at sub-confluence (5,000 cells/well) in 96-well microtitre plates. All drugs and inhibitors were diluted in complete media. Controls were treated with vehicle alone. Cells were treated with PMA or EBC-46 the day after seeding and cultured for 4 days. To measure inhibition of cell growth, attached cell lines were assayed using sulforhodamine B (SRB) [24], [25]. The experiments were repeated at least twice and the mean ± SD was determined in Prism 6 (GraphPad Software, San Diego, CA).

Animal ethics statement

This study was performed in strict accordance with the recommendations in the Australian Code for the Care and Use of Animals for Scientific Purposes 8th Edition (2013), of the National Health and Medical Research Council of Australia. All protocols were reviewed and approved by the QIMR Berghofer Medical Research Institute Animal Ethics Committee (QIMR-AEC), approval numbers A0106-042M and A0404-606M. All mice were housed in a specific pathogen free (SPF) facility, with 12 hours light/dark cycle and continual access to food and water. All mice were monitored daily and tumor volume measured at least twice weekly, recorded using digital calipers and expressed as mm3 according to the formula A×b×b×0.5 where A the length and b the measured breadth of the tumor. Mice were also assessed for clinical signs according to a QIMR-AEC approved clinical score sheet for distress during the period of the experiment to determine whether the treatments (i.e. tumor burden and effects of drugs) were causing distress to the mice to a degree and to where they should be euthanased (Table 1). Scores for each parameter were summed to give a possible total of 8. Less than 3 was considered a mild clinical score, between 3 and 6 was considered a moderate clinical score, and over 6 was considered a severe clinical score. The experiment was ceased when an unacceptable clinical score (>6) was reached, or the cumulative tumor burden of the mouse exceeded 1,000 mm3. Mice were humanly euthanized by asphyxiation at the end of the experiment.

Table 1

Clinical scoring for Drug Treated and Tumor Bearing Mice.

EBC-46 treatment of tumors in mice

SK-MEL-28, MM649, FaDu (2×106) or B16-F0 (1×105) cells were injected (two tumors per mouse) on the hindquarter of 5 week old immunocompromised BALB/c Foxn1nu mice or C57BL/6J mice. When the tumors reached approximately 50 mm3 (SK-MEL-28 and MM649) or 100 mm3 (FaDu and B16-F0), mice in the control group were treated with vehicle (20% propylene glycol in water, 50 µl), and the treatment group received 50 nmol (30 µg) EBC-46 in vehicle, via a single intra-tumoral injection. Mice were euthanized when the cumulative tumor burden per mouse exceeded 1,000 mm3 or at the end of the experiment.

Pharmacokinetic study of EBC-46 in tumor and non-tumor-bearing mice

Nine BALB/c Foxn1nu mice were injected with 2×106 MM649 melanoma cells, one tumor per mouse. Tumors were monitored until they reached approximately 100 mm3. Mice were then treated by injecting 50 nmol (30 µg) EBC-46 either into the tumor (tumor bearing mice) or into normal skin (sub-cutaneously, 9 tumor-free mice). Blood (maximum of 150 µl) was collected from the tail vein by nicking at the base of the tail at 30 min, 1, 2, 4, 8 and 24 h post-treatment (3 animals at 30 min and 4 h, 3 animals at 1 and 8 h, 3 animals at 4 and 24 h) into a lithium heparin Microvette CB300 blood collection system (Sarstedt, Numbrecht, Germany), and processed to plasma by centrifugation at 2,000 g for 5 min at 20°C until separation occurred. Plasma was frozen at −80°C until analysed. Samples were analyzed using a specifically developed HPLC method to detect EBC-46 in mouse serum against a spiked standard curve. Erythema and oedema were rated using a five point scale (0 to 4; none to severe) 24 h after injection. Weight of animals was determined immediately prior to, and 24 h following treatment.

Ex vivo analysis of tumor cell survival

SK-MEL-28 or FaDu cells were injected (two tumors per mouse) on the hindquarter of 5 week old immunocompromised BALB/c Foxn1nu mice. When the tumors reached approximately 100 mm3, mice in the control group were treated with 20% propylene glycol in water, and the treatment group received 50 nmol (30 µg) EBC-46 via a single intra-tumoral injection. Mice were euthanized at time of injection, 1, 2, 4, 8 and 24 h post-treatment with vehicle or EBC-46, and tumors were harvested. Tumors were dissected, briefly dissociated with collagenase A, and finally resuspended in culture medium. Serial 3-fold dilutions of the cell suspension were cultured in vitro for 6 days, and the SRB assay used to compare the growth of viable EBC-46-treated tumor cells with that of vehicle treated controls.

EBC-46 treatment in neutrophil-depleted mice

SK-MEL-28 cells (2×106) were injected (two tumor sites per mouse) into the flanks of thirty 5- to 6-week old male BALB/c Foxn1nu mice (n = 5 mice and n = 10 tumors/group). When tumors had reached >50 mm3, ten mice were given i.p. injections of rat anti-neutrophil targeting antibody mLy-6G (100 µg in PBS; clone 1A8, Cat. # BE0075-1) or rat IgG2a isotype control (clone 2A3, Cat. # BE0089) from BioXCell (West Lebanon, NH). The antibodies were injected on days −2, 0, and 2, relative to initiation of vehicle or EBC-46 (25 nmol, 15 µg) treatment on day 0. An additional ten control mice received no antibody. The tumors on a total of 15 mice (5 each of no antibody, IgG2a isotype control or anti-mLy-6G antibody) were treated with 25 nmol EBC-46 per site (15 µg in 20% propylene glycol in water at 300 µg/ml, 50 µl injection), while the tumors on the remaining 15 mice were treated with 50 µl 20% propylene glycol in water only. Blood was taken from tail tips on Days −2, 0 and 2, and then twice weekly, smeared, and air dried on glass slides before being stained with Quick Dip (Fronine Laboratory Supplies, Rivertone, NSW, Australia). Tumor size was measured with calipers twice weekly. Mice were euthanized when the cumulative tumor burden per mouse exceeded 1,000 mm3 or at the end of the experiment.

In vitro permeability assay

HUVEC cells (Invitrogen/Life Technologies) were grown as described by the manufacturer and used at passage 4 to 6. Media and supplements (M200 [Cat. No. M200PRF500] and Low Serum Growth Supplement [Cat. No. S-003-10] respectively, Life Technologies) were prepared as directed. The In vitro Vascular Permeability Kit was from Millipore (Billerica, MA; Cat. No. ECM642). All assays were performed as described by the manufacturer. Assays were performed in at least triplicate wells.

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Results

EBC-46 is a novel Protein Kinase C-activating compound

EBC-46. (12-Tigloyl-13-(2-methylbutanoyl)-6,7-epoxy-4,5,9,12,13,20-hexahydroxy-1-tigliaen-3-one; C30H42O10; 562.65 g/mol) is a novel compound purified from a commercially-sustainable natural source. It is structurally similar to the prototypic PKC-activating compound phorbol 12-myristate 13-acetate (PMA), but considerably less hydrophobic due to short ester side-chains and hydroxylation in the B ring (Figure 1A). To investigate if EBC-46 activated PKC, we initially examined the production of reactive oxygen species following treatment of PMN cells. The induction of oxidative burst in human PMN by PKC activators has been previously described [26], [27]. Treatment of PMN cells with 175 nM (100 ng/ml) PMA lead to an increase in fluorescent signal that corresponded with the oxidation of dihydroethidium bromide to fluorescent ethidium bromide. Pre-treatment with 1 µM bisindolylmaleimide-l (pan-PKC inhibitor) prevented this increase in fluorescent signal (Figure 1B, right) indicating PKC-activation dependence. Similarly, treatment of PMN cells with 175 nM (100 ng/ml) EBC-46 also led to an increase in fluorescent signal by oxidation, that was prevented by pre-treatment with bisindolylmaleimide-l (Figure 1B, left).

Figure 1

EBC-46 is a novel Protein Kinase C-activating compound.

Transient transfection of HeLa cells with PKC isoforms tagged to EGFP and subsequent treatment with PMA resulted in efficient translocation to the plasma membrane of –α, -βI, βII, -γ, -δ, -θ, and –η subtypes (Figure 1C). Modest translocation of PKC-ε was observed following 1 h treatment, consistent with previous results from others [28]. As expected, no translocation was seen for the atypical PKC-ι or -ζ isoforms lacking a C1 DAG-binding domain after treatment with PMA. Treatment with EBC-46 resulted in high percentage of cells showing translocation of PKC-βI and –βII isoforms, with less translocation seen for the –α, –γ, –δ, and -ε isoforms. No translocation of the atypical PKC-ι or -ζ isoforms was observed following EBC-46 treatment. Interestingly, EBC-46 treatment did not result in significant translocation of the –θ and –η isoforms to the plasma membrane suggesting that PMA and EBC-46 differ in their selectivity and/or potency towards specific PKC isoforms. These results were confirmed in SK-MEL-28 cells (Figure S1). However, transient transfection of PKC-ε or -ι isoforms was toxic to SK-MEL-28 cells, while transfection of PKC-δ localized to the mitochondrial membrane and treatment with PMA or EBC-46 had no effect (Figure S1). EBC-46 treatment resulted in the translocation of endogenous PKC-α to the plasma membrane in HeLa cells, similar to that with PMA (Figure 1D). Further, an in vitro kinase assay demonstrated an increase of PKC kinase activity in HeLa cells treated with EBC-46, particularly at 17.5 µM (10 µg/ml) (Figure 1E). Taken together, these results suggest that EBC-46 is a novel activator of PKC, in particular of the –β isoforms.

EBC-46 is efficacious in vivo, independent of tumor cell sensitivity in vitro

Previous studies have shown activators of PKC to induce cell death in cancer cells in vitro and in vivo [14]. We therefore tested clonogenic-type cell survival of EBC-46 in comparison to PMA. Treatment with PMA for 4 days led to almost complete cell death at 52.5 µM for both B16-F0 and SK-MEL-28 cells, with the 50% lethal dose (LD50) of approximately 17.5 µM for each cell line (17.63±0.13 and 17.81±0.15 µM respectively). In comparison, EBC-46 was less potent for cell killing than PMA in vitro (Figure 2A). Treatment with EBC-46 for the same period led to complete cell killing at 175 µM, with an LD50 of approximately 52.5 µM for each cell line (B16-F0, 52.25±0.11; SK-MEL-28, 52.60±0.18 µM). Similar results were obtained for a panel of cell lines, including HeLa, FaDu, HT-29, MCF-7, MM649 and MC-38 (Figure S2); in each case EBC-46 was less potent for cell killing than PMA in vitro. However, these results show that EBC-46 has a direct effect on cell survival in vitro.

Figure 2

EBC-46 efficacy in vivo is independent of tumor cell sensitivity in vitro.

We tested the in vivo efficacy of both PMA and EBC-46 in the B16-F0/C57BL/6J mouse melanoma model via intra-tumoral injection. Each mouse was injected with 500,000 B16-F0 cells per flank, and the tumors allowed to reach 100 mm3. Intra-tumoral injection of vehicle alone (20% propylene glycol in water) into established tumors had no effect, with all mice reaching the maximal tumor burden 4 days after treatment (Figure 2B). Intra-lesional injection of 50 nmol (30 µg) PMA in vehicle delayed tumor growth compared to vehicle alone, with all mice reaching maximal tumor burden 20 days post-treatment. Importantly, all treated sites relapsed. In contrast, intra-lesional treatment with 50 nmol (30 µg) EBC-46 led to an initial swelling of the tumor site followed by rapid ablation of the tumors. Treatment with a single bolus injection of 50 nmol (30 µg) EBC-46 showed a significant (p = 0.0004, Log-rank (Mantel-Cox) test) extension of time to euthanasia due to tumor burden compared to treatment with PMA, indicating anti-tumor efficacy. There was more than 70% total cure in the EBC-46 treatment group that was censored in the data due to single sites recurring of the two treated per mouse (15 of 20; 75% cured).

We further evaluated the anti-tumor efficacy of EBC-46 in additional mouse models of cancer. Intra-lesional treatment of BALB/c Foxn1nu mice, xenografted with SK-MEL-28 or MM649 human melanoma tumors (>50 mm3), with 50 nmol (30 µg) EBC-46 again led to an initial swelling of the tumor treatment site followed by ablation of the tumors compared to treatment with vehicle alone (20% propylene glycol in water). There were three recurrences after EBC-46 treatment of SK-MEL-28 tumors within the 40 day observation period (2>100 mm3, 1<100 mm3), and a single recurrence of a MM649 tumor within the 150 day observation period (>100 mm3) (Figure 2C and D respectively). Differences in tumor recurrence was highly significant for both SK-MEL-28 and MM649 (p<0.0001, Log-rank (Mantel-Cox) Test). In the MM649 tumor model, all other sites treated with EBC-46 in this study remained tumor free with no recurrence for 12 months (data not shown). Additional models showed efficacy against head and neck cancer (FaDu, Figure S3 and S4A) and colon cancer (HT-29, Figure S4B; MC-38, Figure S4C). These results suggest that a single bolus intra-lesional treatment with EBC-46 can lead to an enduring ablation of tumor cell growth in vivo.

Pharmacokinetic studies suggest EBC-46 remains at the tumor injection site

We wished to determine the pharmacokinetic profile of EBC-46 following a single intra-tumoral or sub-cutaneous injection into mice either bearing or not bearing tumors, respectively. Intra-tumoral treatment with EBC-46 of BALB/c Foxn1nu mice xenografted with MM649 melanoma cells led to significant erythema and oedema of the injection sites, as assessed 24 hours following injection. Sub-cutaneous treatment of normal skin to mimic intra-tumoral treatment (non-tumor bearing mice) led to significantly less erythema (p = 0.0021, t-test; Figure 3A) and oedema (p = 0.0007, t-test; Figure 3B), as assessed 24 hours after treatment. Mice without tumors that were treated sub-cutaneously with 50 nmol (30 µg) EBC-46 lost significantly more weight in 24 h (4.73±0.91% loss) than those mice treated by intra-tumoral injection with EBC-46 (0.70±0.99% loss; p = 0.0087, t-test; Figure 3C). Additionally, blood was collected following administration of EBC-46 to mice, and a quantitative HPLC assay used to determine the level of EBC-46 in the plasma. Results show that less EBC-46 was detected in serum from tumor-bearing mice treated by intra-lesional injection compared to non-tumor bearing mice treated by sub-cutaneous injection (Figure 3D), suggesting that the compound is retained at the tumor site.

Figure 3

EBC-46 treatment induces greater effects when injected into tumors compared to normal skin.

Neutrophils have a minor role in EBC-46 anti-cancer activity

Previous studies have outlined the role of neutrophils in anti-tumor efficacy of PKC agonists [15], [29]. The importance of neutrophils for the anti-cancer activity of EBC-46 was investigated by using an antibody (anti-mLy-6G, clone 1A8) to deplete these cells in mice bearing SK-MEL-28 tumors prior to treatment. SK-MEL-28 tumors were allowed to grow to approximately 100 mm3 prior to injection of the antibodies on days −2, 0 and 2 relative to treatment with EBC-46 or vehicle alone. The percentage of neutrophils in WBC counts in peripheral blood were determined for each of the groups. Following treatment with anti-Ly-6G antibody, the percentage of neutrophils in the peripheral blood fell from 62% of total leukocytes to 6% after a single treatment (Day 0), while the isotype control antibody had no effect (data not shown). Tumors in mice receiving the anti-Ly-6G neutrophil antibody grew slightly more rapidly compared to SK-MEL-28 tumors receiving either no-antibody or isotype control (IgG2a) antibody following a single treatment with bolus vehicle (Figure 4A), consistent with previous observations [15]. Ablation of the SK-MEL-28 tumors following treatment with 25 nmol (15 µg) EBC-46 (a lower dose of EBC-46 was used to reduce efficacy) was apparent in all groups (Figure 4B). There were no tumor recurrences in the group treated with EBC-46 alone in the 48 day observation period. However, we observed 4 recurrences in the mice receiving the anti-Ly-6G antibody compared to a single recurrence in the mice treated with the isotype control (IgG2a) antibody (Figure 4B). Although these data were not statistically significant (p = 0.30, Fisher’s exact test), these results may suggest that neutrophils play only a minor role in the anti-tumor efficacy of EBC-46 in this model.

Figure 4

EBC-46 anti-cancer efficacy is PKC-dependent.

EBC-46 anti-cancer efficacy is PKC-dependent

We wished to assess if PKC activation by EBC-46 was necessary for the anti-cancer efficacy of the compound. We therefore tested the in vivo efficacy of EBC-46 in BALB/c Foxn1nu mice xenografted with B16-F0 mouse melanoma cells via intra-tumoral injection in the presence or absence of bisindolylmaleimide-1, a PKC inhibitor. Each mouse was injected with 500,000 B16-F0 cells per injection site, and the tumors allowed to reach >50 mm3. Intra-tumoral injection of vehicle alone (20% propylene glycol in water) into established tumors had no effect, with all tumors continuing to increase in size over the following 8 days (Figure 4C). Intra-lesional injection of 16.7 nmol (10 µg) EBC-46 (lower dose to reduce efficacy) in vehicle led to a rapid ablation of the tumors (p<0.0001, t-test, compared to vehicle treated sites; Figure 4C), with only 25% of treated sites showing tumor presence 8 days after treatment (9 of 12 sites with no tumor, Figure 4D). In contrast, intra-lesional treatment with 16.7 nmol (10 µg) EBC-46 after pre-treatment with 5 µM bisindolylmaleimide-1 for 1 h, resulted in the majority of tumors continuing to grow (p = 0.0024, t-test compared to EBC-46 alone treated sites; Figure 4C), with 83.3% of treated sites showing the presence of tumors (2 of 12 sites with no tumor, Figure 4D). Co-injection of EBC-46 with a PKC inhibitor significantly reduced the efficacy of treatment, indicating that the anti-cancer efficacy of EBC-46 is PKC-dependent.

Treatment with EBC-46 results in rapid loss of tumor cell viability in vivo

Treatment with EBC-46 led to a dramatic ablation of tumors following intra-lesional injection. We therefore wished to examine the timing of loss of viability of tumor cells following treatment with EBC-46 in an ex vivo assay. Two tumor models were used, namely SK-MEL-28 and FaDu human tumor cells, in BALB/c Foxn1nu mice. Tumors were allowed to reach approximately 100 mm3 before treatment with 50 nmol (30 µg) EBC-46 or vehicle (50 µl 20% propylene glycol in water), and then removed, dissociated into single cell suspension and assayed for clonogenic growth in vitro. The results show that the tumor cells had greatly reduced viability 4 hours after treatment with EBC-46. The results were similar for both SK-MEL-28 (Figure 5A) and FaDu (Figure 5B) tumors. In contrast, tumors treated with vehicle alone remained fully viable. These results suggest that tumor cell viability is compromised following treatment with 50 nmol (30 µg) EBC-46 after as little as 2 to 4 h.

Figure 5

EBC-46 kills tumor cells rapidly in vivo.

As indicated above, intra-lesional treatment with EBC-46 led to a rapid swelling of the tumor site. We therefore examined FaDu human head and neck cancer tumors xenografted into BALB/c Foxn1nu mice after treatment with EBC-46 or vehicle alone by histology. Intra-lesional injection of EBC-46 into FaDu tumors also resulted in red cell extravasation within the tumor 1 to 2 h following treatment (Figure 5D). We also observed that tumor nuclei became pale and shrunken 2 to 4 h after treatment, and the tumor cells disorganized 4 to 8 h following EBC-46 treatment (Figure 5D), mirroring the loss of viability seen in the ex vivo measurement of efficacy (Figure 5A and B). Similar to other PKC agonists, treatment of normal skin with EBC-46 led to an apparent dilation of smaller blood vessels, and some red cell extravasation in the dermis and subcutis of the skin up to 8 h following treatment (Figure S5B). However, there was no evidence of remaining red cell extravasation 24 h after treatment.

EBC-46 causes permeability of endothelial cells within tumors

It has been previously reported that activation of PKC, especially of PKC-β, can induce endothelial cell activation and permeability [30], [31]. Further, it was recently shown that PKC agonists can cause endothelial cell activation and permeability in vivo by disruption of structural integrity [29]. We therefore examined blood vessel integrity in FaDu tumors following EBC-46 treatment using detection of CD31 using immunohistochemistry. While treatment of FaDu tumors with vehicle alone led to no apparent disruption of vessel morphology, intra-lesional injection of EBC-46 resulted in the loss of structural integrity from as early as 30 min following treatment (Figure 6A). CD31 immunostaining showed vessels that were dilated and incomplete when compared to untreated tumors or tumors treated with vehicle alone (Figure 6A and B). Treatment of normal skin with EBC-46 led to less apparent damage, particularly of larger vessels, with the majority remaining structurally intact, although vessel swelling was evident (Figure S6A and B). We therefore examined the effect of EBC-46 on cultured monolayers of human umbilical vascular endothelial (HUVEC) cells. Monolayers of HUVEC cells were treated with 350 µM (200 µg/ml) EBC-46 (similar concentration to that present in the tumor; assuming 100 mm3 tumor volume and injection of 50 µl volume, a three-fold dilution of the initial 1,050 µM/600 µg/ml concentration) for 30 min, before being assessed for permeability using FITC-Dextran. The results show that short term, high dose treatment with EBC-46 leads to significantly increased permeability of the HUVEC cell monolayer (p = 0.0013, t-test; Figure 6C). Propidium iodide uptake experiments on HUVEC cells treated with EBC-46 showed that cells were compromised rapidly (5 min; data not shown). This uptake of propidium iodide by damaged HUVEC cells was PKC-dependent, as evidenced by inhibition with the pan-PKC inhibitor bisindolylmaleimide-1 (Figure 6D).

Figure 6

EBC-46 causes disruption and permeability of endothelial cells within tumor.
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Discussion

Activation of specific PKC isoforms in vascular endothelial cells, particularly the PKC-β isoforms, has previously been shown to induce permeability [30], [31]. Here we show that intra-lesional treatment with EBC-46, a novel PKC-activating compound with apparent specificity for PKC-β isoforms, induces permeability of endothelial cell monolayers in vitro, as well as vascular swelling and apparent disruption of vessel morphology in vivo. Further, sub-cutaneous injection of EBC-46 into normal skin led to significant levels of the drug found in the peripheral circulation. In contrast, intra-lesional injection of EBC-46 resulted in greatly reduced levels detected in the peripheral blood of mice. Additionally, the erythema and oedema observed following EBC-46 administration was significantly higher in mice with tumors compared to mice with normal skin. These results suggest a specificity of vascular damage within tumor sites compared to normal skin leading to anti-cancer efficacy. This specificity may reflect the disorganization and inherent “leakiness” of the vasculature within a solid tumor [32]. We hypothesize that the damage to the tumor vasculature prevents EBC-46 from entering the circulation. There is also a direct effect on tumor cell survival, as no viable tumor cells were evident four hours after injection by ex vivo culture. This is supported by in vitro data which showed treatment with EBC-46 was capable of inhibiting cell survival.

Previous studies elegantly showed that another PKC-activating ingenol ester, Ing3A (ingenol 3-angelate, ingenol mebutate, also known as PEP005) was able to penetrate deeper into the dermis following topical application compared to PMA, as it is a substrate for MDR1/P-glycoprotein (P-gp)/ABCB1 [29]. The authors showed that penetration of PMA after topical application was restricted to the epidermis of the skin, thereby sparing the vasculature in the sub-epidermal compartments and resulting in a lack of anti-tumor activity. Further, Li and colleagues also demonstrated that Ing3A bound to and inhibited P-gp whereas PMA did not [29]. Our results presented here additionally show that direct intra-tumoral injection of PMA only led to a transient reduction of tumor growth followed by a rapid relapse. In contrast, intra-tumoral injection of EBC-46 had an enduring anti-tumor effect.

We were unable to definitively demonstrate that neutrophils contribute significantly to the anti-tumor efficacy of EBC-46 by intra-lesional injection. Our conclusion was that neutrophils play a minor role in overall efficacy of EBC-46 from the experiments presented in this study. This is in contrast with previous work with other PKC activators (Ing3A/PEP005), where neutrophils were required for anti-tumor efficacy [15], [29]. However, the method of delivery used in this study (intra-tumoral injection) is very different compared to that used in the previous studies with the PEP005 (topical application). Further, the anti-neutrophil antibody used here was from a different, more neutrophil-specific hybridoma clone [33] than that used in previous studies. Nevertheless, in the current study approximately 6% of the cells in the peripheral WBC counts were found to be neutrophils.

It is important to note that intra-lesional injection of the prototypic PKC-activator PMA did not lead to a cure of tumors in the current study, but rather an initial shrinking of the tumor followed by a rapid relapse. In contrast, treatment with EBC-46 led to a rapid ablation of the tumor. In greater than 70% of cases, the response and cure was enduring and long term, as demonstrated by the lack of relapse of MM649 tumors over a period of 12 months. PKC activation must clearly play an important role in the action of EBC-46, since pre-treatment with the wide-spectrum PKC inhibitor bisindolylmaleimide-1 resulted in a loss of efficacy in vivo, and prevented endothelial cell dye uptake in vitro. However, we cannot rule out other known targets of diacylglycerol analogues other than PKC isoforms. Recent work has identified that Ing3A/PEP005 binds to and activates members of the RasGRP family of Ras activators, and that this activation may be in part responsible for the anti-cancer activity of the compound [34]. Future studies will investigate if EBC-46 similarly activates molecules in addition to PKC isoforms. In summary, we have identified and characterized EBC-46 as a novel PKC-activating compound. We demonstrate that a single intra-lesional bolus injection is sufficient for the short term regression and ultimate cure of multiple different cancer types in pre-clinical models. EBC-46 is currently being prepared under GMP conditions for use in an upcoming Phase I clinical trial.

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Supporting Information

Figure S1

Translocation of PKC isoforms induced by EBC-46 in SK-MEL-28 cells. PKC-EGFP isoform translocation in transiently transfected SK-MEL-28 cells following 1 h treatment with either 175 nM (100 ng/ml) PMA or EBC-46. Data was obtained from assessment of at least 50 cells per well from each of triplicate transient transfection experiments. Error bars – standard deviation. a – no data available due to mitochondrial location prior to and after treatment; b – no data available as isoform was toxic to SK-MEL-28 cells.

(TIF)

Click here for additional data file.(341K, tif)

Figure S2

Cell survival assays following treatment with EBC-46. Dose response for cell killing by EBC-46 compared to PMA. Cells were treated with the indicated doses of either EBC-46 (blue) or PMA (red) for 4 days, before assay for cell survival using the sulforhodamine B assay. Data shown are mean ± SD from triplicate readings from three independent experiments, n = 3.

(TIF)

Click here for additional data file.(652K, tif)

Figure S3

Treatment of FaDu tumors with 30 µg EBC-46 or vehicle alone. 2×106 FaDu tumor cells were injected were injected (two tumors per mouse) on the hindquarter of 5 week old immuno-compromised BALB/c Foxn1nu mice. When the tumors had reached approximately 100 mm3, mice in the control group were treated with vehicle (20% propylene glycol in water, 50 µl) and the treatment group received 50 nmol (30 µg) EBC-46 in vehicle via a single intra-tumoral injection. Figure shows tumor appearance prior to treatment, 1 h following treatment, and 2, 5 and 11 days post treatment of tumors treated with vehicle alone (left) or 50 nmol (30 µg) EBC-46 (right). Also shown are ablated tumors 21 days following treatment with 50 nmol (30 µg) EBC-46. No vehicle only control tumors are shown due to the animals being euthanized at day 12 following treatment due to excessive tumor volume.

(TIF)

Click here for additional data file.(1.8M, tif)

Figure S4

EBC-46 Efficacy against head and neck or colon cancer tumors. A. Tumor volume of FaDu HNSCC line in BALB/c Foxn1nu mice. B. Kaplan Meier plot of HT-29 tumor volume reaching greater than 100 mm3 in BALB/c Foxn1nu mice. C. Kaplan Meier plot of MC-38 tumor volume reaching greater than 100 mm3 in C57BL/6J mice. Grey – vehicle (20% propylene glycol in water); Black – 50 nmol (30 µg) EBC-46 (in vehicle).

(TIF)

Click here for additional data file.(257K, tif)

Figure S5

Effect of EBC-46 on normal skin. Normal skin of BALB/c Foxn1nu mice was treated with either A. 50 µl vehicle (20% propylene glycol in water) or B. 50 nmol (30 µg) EBC-46 in vehicle. Arrows indicate examples of dilated blood vessels. Scale bar  = 100 µm.

(TIF)

Click here for additional data file.(5.7M, tif)

Figure S6

Effect of EBC-46 on normal skin vasculature. Normal skin of BALB/c Foxn1nu mice was treated with either A. 50 µl vehicle (20% propylene glycol in water) or B. 50 nmol (30 µg) EBC-46 in vehicle. Arrows indicate examples of intact blood vessels. Scale bar  = 100 µm.

(TIF)

Click here for additional data file.(4.8M, tif)
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Acknowledgments

We thank TetraQ Pty. Ltd. for performing the chromatographic assay to determine the level of EBC-46 in the plasma (under a fee-for-service agreement with QBiotics Ltd.).

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Funding Statement

This work was supported by the National Health and Medical Research Council of Australia Development Grant, Number APP1017676 (PGP, GMB, PWR). MMAD was supported by the University of Queensland International Research Tuition Award (UQIRTA) and a University of Queensland Research Scholarship (UQIRS). GMB was supported by a Smart Futures Researcher-in-Residence fellowship from the Queensland Government, and is currently supported by the Wilson Fellowship for Skin Cancer Research administered by the Perpetual Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Data Availability

The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information files.

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Articles from PLoS ONE are provided here courtesy of Public Library of Science

Frankincense oil kills cancer cells while boosting the immune system

Frankincense oil is a powerful medicinal oil that can not only boost the immune system but also kill cancer cells, a number of studies have shown. (NaturalNews) by: David Gutierrez, staff writer
One of the most significant recent studies was conducted by researchers from the University of Leicester, England, in 2013. The researchers found that the naturally occurring frankincense compound acetyl-11-keto-beta-boswellic acid (AKBA) targeted and destroyed ovarian cancer cells. The findings were particularly significant because they showed that AKBA had this effect even in late-stage ovarian cancer patients, not just in laboratory trials performed on isolated cells.

“Frankincense is taken by many people with no known side effects,” lead researcher Kamla Al-Salmani said. This finding has enormous potential to be taken to a clinical trial in the future and developed into an additional treatment for ovarian cancer.”

Kills cancer and reduces radiation side effects

The Leicester findings build on a large and still growing body of evidence that frankincense and its compounds have powerful immune-boosting and cancer-fighting benefits.

A study published in BMC Complementary and Alternative Medicine in 2009, for example, found that the herbal form of frankincense triggered death in bladder cancer cells by activating several different cellular pathways. Another study, conducted by researchers from Nihon University in Tokyo and published in Biological and Pharmaceutical Bulletin, showed that several chemical components of frankincense were able to kill three separate human neuroblastoma cell lines. The same study also found that frankincense inhibited the growth of Epstein-Barr virus.

Neuroblastoma is a type of cancer that forms in nerve cells and primarily affects young children. Other studies have shown that frankincense and its components can kill cancers of the brain, breast, colon, pancreas, prostate and stomach.

Frankincense may also help mitigate the often-debilitating side effects of cancer treatment. One study, published in the journal Cancer in 2011, was performed on brain cancer patients experiencing cerebral edema (swelling) as a side effect of radiation therapy. The researchers found that 60 percent of participants given frankincense experienced a 75 percent reduction in cerebral swelling, a potent enough result for the authors to recommend frankincense as a potential alternative to steroids, the current favored treatment. Side effects of steroids can include headaches, blurred vision and migraines.

All-around immune booster

Frankincense’s cancer-fighting benefits seem to come, in part, from its potent effects on the immune system. One study, conducted by researchers from Baylor University Medical Center, found that acts upon the expression of genes that help regulate the immune system, leading to cancer cell death. Another study, published in Phytotherapy Research, found that mice given frankincense exhibited increases in several key markers of immune function, primarily levels of white blood cells (lymphocytes) and anti-inflammatory activity.

Numerous studies confirmed frankincense as a powerful anti-inflammatory. This, along with its other immune-boosting properties, may in part explain its usefulness in fighting infection and in treating autoimmune conditions such as asthma, rheumatoid arthritis and inflammatory bowel disease (IBD).

Frankincense can also be used to heal skin, including from acne and scarring, and can reduce anxiety levels.

If you wish to incorporate frankincense as a regular natural health booster, it can be taken as an undiluted essential oil on the skin or as a few drops under the tongue. It can also be diffused and breathed in for respiratory conditions. Frankincense can also be purchased and consumed in powdered capsule form.

There are numerous species of frankincense, including Boswellia carteri, B. serrata and B. sacra. All three of these species have shown powerful anti-cancer effects in scientific tests.

B. carteri, native to east Africa, has been the species most heavily studied. B. sacra, also known as “sacred frankincense,” was until recently restricted to use by the Saudi royal household, and could only be purchased in Oman. Recently, however, a distillery opened up in Oman to produce essential oil of B. sacra for public sale.

Sources for this article about Frankincense oil include:
http://blogs.naturalnews.com
https://draxe.com/frankincense-oil-cancer/
http://www.naturalnews.com/025892_cancer_frankincense_oil.html

Natural cancer cure – cancer cells died in 42 days

natural cure cancer

 

This Famous Austrian’s Juice Cured Over 45,000 People.

Rudolf Brojs from Austria has dedicated his whole life to finding the best natural cure for cancer.He actually made a special juice that gives excellent results for treating cancer. He has cured more than 45, 000 people who suffered from cancer and other incurable diseases with this method. Brojs said that cancer can survive only with the help of proteins.

So, he developed a special eating program for 42 days, during which you drink only tea and a special vegetable juice whose main ingredient is beetroot.

During this period of 42 days, cancer cells die and starve, while entire body’s health improves.
Rudolf’s juice is made only from ecologically grown vegetables. This juice can be made at home from home-grown vegetables, and it contains:

  • beetroot (55%),
  • carrots (20%),
  • celery root (20%),
  • potatoes (3%)
  • radishes (2%).

Preparation for natural cancer cure:

Put all these ingredients in a blender, mix them well and that`s all, your juice is ready!

It is important to note that you should not exaggerate with the juice, but you should take as much as your organism needs.

Beetroot is a well-known cure for leukemia. With its amino acid betaine, it has anti-cancer properties. The therapy of beetroot has a proven positive effect on leukemia and many other types of cancer.

If you regularly consume beetroot, it will help you against diseases caused by oxidative stress, and beetroot’s fiber can lower blood cholesterol levels up to 40%. It also normalizes blood pressure and helps in maintaining the blood vessels elasticity. Therefore, beetroot is very effective in the treatment of many diseases caused by toxins.

It is especially recommended for pregnant women to use beetroot because it is full of folic acid which prevents many diseases of newborns. Beetroot juice stimulates the liver and gall bladder and also prevents constipation.

If you combine it with carrots, beetroot can help you for gout, kidney, and gallbladder. It also helps with headaches, toothaches, dysentery, pain in the bones, skin and menstrual problems.
source: allabouthealthyfood.com